Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study
Abstract Background This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET-CT) scans during neoadjuvant extremity soft tissue sarcoma (ESTS) treatment. Results During neoadjuvan...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-06-01
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| Series: | EJNMMI Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13550-018-0397-1 |
| _version_ | 1818249367633526784 |
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| author | Marc G. Stevenson Lukas B. Been Harald J. Hoekstra Albert J. H. Suurmeijer Ronald Boellaard Adrienne H. Brouwers |
| author_facet | Marc G. Stevenson Lukas B. Been Harald J. Hoekstra Albert J. H. Suurmeijer Ronald Boellaard Adrienne H. Brouwers |
| author_sort | Marc G. Stevenson |
| collection | DOAJ |
| description | Abstract Background This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET-CT) scans during neoadjuvant extremity soft tissue sarcoma (ESTS) treatment. Results During neoadjuvant treatment, hyperthermic isolated limb perfusion (HILP) and preoperative external beam radiotherapy (EBRT), 11 patients underwent three 18F-FDG PET-CT scans. The first scan was made prior to the HILP, the second after the HILP but prior to the start of the EBRT, and the third prior to surgical resection. An automatically drawn VOIauto, a manually drawn VOIman, and two gradient-based semi-automatically drawn VOIs (VOIgrad and VOIgrad+) were obtained. Maximum standardized uptake value (SUVmax), SUVpeak, SUVmean, metabolically active tumor volume (MATV), and total lesion glycolysis (TLG) were calculated from each VOI. The correlation and level of agreement between VOI delineation techniques was explored. Lastly, the changes in metabolic tumor activity were related to the histopathologic response. The strongest correlation and an acceptable level of agreement was found between the VOIman and the VOIgrad+ delineation techniques. A decline (VOIman) in SUVmax, SUVpeak, SUVmean, TLG, and MATV (all p < 0.05) was found between the three scans. A > 75% decline in TLG between scan 1 and scan 3 possibly identifies histopathologic response. Conclusions The VOIgrad+ delineation technique was identified as most reliable considering reproducibility when compared with the other VOI delineation techniques during the multimodality neoadjuvant treatment of locally advanced ESTS. A significant decline in metabolic tumor activity during the treatment was found. TLG deserves further exploration as predictor for histopathologic response after multimodality ESTS treatment. |
| first_indexed | 2024-12-12T15:35:22Z |
| format | Article |
| id | doaj.art-890e308bcb7f480d8deb7a6c3aceb7b3 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-12T15:35:22Z |
| publishDate | 2018-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-890e308bcb7f480d8deb7a6c3aceb7b32022-12-22T00:20:01ZengSpringerOpenEJNMMI Research2191-219X2018-06-018111110.1186/s13550-018-0397-1Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility studyMarc G. Stevenson0Lukas B. Been1Harald J. Hoekstra2Albert J. H. Suurmeijer3Ronald Boellaard4Adrienne H. Brouwers5Department of Surgical Oncology, University Medical Center Groningen, University of GroningenDepartment of Surgical Oncology, University Medical Center Groningen, University of GroningenDepartment of Surgical Oncology, University Medical Center Groningen, University of GroningenDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of GroningenDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of GroningenDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of GroningenAbstract Background This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET-CT) scans during neoadjuvant extremity soft tissue sarcoma (ESTS) treatment. Results During neoadjuvant treatment, hyperthermic isolated limb perfusion (HILP) and preoperative external beam radiotherapy (EBRT), 11 patients underwent three 18F-FDG PET-CT scans. The first scan was made prior to the HILP, the second after the HILP but prior to the start of the EBRT, and the third prior to surgical resection. An automatically drawn VOIauto, a manually drawn VOIman, and two gradient-based semi-automatically drawn VOIs (VOIgrad and VOIgrad+) were obtained. Maximum standardized uptake value (SUVmax), SUVpeak, SUVmean, metabolically active tumor volume (MATV), and total lesion glycolysis (TLG) were calculated from each VOI. The correlation and level of agreement between VOI delineation techniques was explored. Lastly, the changes in metabolic tumor activity were related to the histopathologic response. The strongest correlation and an acceptable level of agreement was found between the VOIman and the VOIgrad+ delineation techniques. A decline (VOIman) in SUVmax, SUVpeak, SUVmean, TLG, and MATV (all p < 0.05) was found between the three scans. A > 75% decline in TLG between scan 1 and scan 3 possibly identifies histopathologic response. Conclusions The VOIgrad+ delineation technique was identified as most reliable considering reproducibility when compared with the other VOI delineation techniques during the multimodality neoadjuvant treatment of locally advanced ESTS. A significant decline in metabolic tumor activity during the treatment was found. TLG deserves further exploration as predictor for histopathologic response after multimodality ESTS treatment.http://link.springer.com/article/10.1186/s13550-018-0397-1Soft tissue sarcoma18F-FDG PET-CTLimb perfusionPreoperative radiotherapy |
| spellingShingle | Marc G. Stevenson Lukas B. Been Harald J. Hoekstra Albert J. H. Suurmeijer Ronald Boellaard Adrienne H. Brouwers Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study EJNMMI Research Soft tissue sarcoma 18F-FDG PET-CT Limb perfusion Preoperative radiotherapy |
| title | Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study |
| title_full | Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study |
| title_fullStr | Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study |
| title_full_unstemmed | Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study |
| title_short | Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study |
| title_sort | volume of interest delineation techniques for 18f fdg pet ct scans during neoadjuvant extremity soft tissue sarcoma treatment in adults a feasibility study |
| topic | Soft tissue sarcoma 18F-FDG PET-CT Limb perfusion Preoperative radiotherapy |
| url | http://link.springer.com/article/10.1186/s13550-018-0397-1 |
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