The main side effects of statins in clinical practice
Statins have long occupied a central place in cardiovascular medicine, being an integral component of the prevention and treatment of atherosclerotic cardiovascular diseases (coronary heart disease and its main clinical forms, angina pectoris and myocardial infarction; transient ischemic attacks, is...
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| Format: | Article |
| Language: | English |
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Eco-vector
2022-07-01
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| Series: | Клиническая практика |
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| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/108076/pdf |
| _version_ | 1827845385725411328 |
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| author | Aleksey M. Chaulin |
| author_facet | Aleksey M. Chaulin |
| author_sort | Aleksey M. Chaulin |
| collection | DOAJ |
| description | Statins have long occupied a central place in cardiovascular medicine, being an integral component of the prevention and treatment of atherosclerotic cardiovascular diseases (coronary heart disease and its main clinical forms, angina pectoris and myocardial infarction; transient ischemic attacks, ischemic strokes, etc.). By blocking a key enzyme of cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA-reductase), statins normalize the parameters of the lipid spectrum, primarily, the serum levels of atherogenic low-density lipoprotein cholesterol. However, in addition to the beneficial effects of statins, side effects are also characteristic, which are a significant problem in modern clinical practice due to the fact that they can cause dangerous disorders, forcing physicians to reduce dosages or completely cancel these drugs. Understanding the side effects and the mechanisms underlying their formation is important for improving the measures for the early detection, prevention and treatment of those disorders. This article discusses such side effects of statins as myotoxicity, hepatotoxicity, nephrotoxicity. The pathogenetic mechanisms underlying these toxic effects of statins are discussed. A particular attention is paid to the effect of statins on the oxidative stress, the mechanisms of oxidative damage to cellular macromolecules (lipids, proteins and DNA) and their potential role in the development of myotoxicity, hepatotoxicity and nephrotoxicity. |
| first_indexed | 2024-03-12T08:56:56Z |
| format | Article |
| id | doaj.art-890e3494e6214b4da6acb6ac7b171dde |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T08:56:56Z |
| publishDate | 2022-07-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-890e3494e6214b4da6acb6ac7b171dde2023-09-02T15:55:30ZengEco-vectorКлиническая практика2220-30952618-86272022-07-011329810710.17816/clinpract10807678325The main side effects of statins in clinical practiceAleksey M. Chaulin0https://orcid.org/0000-0002-2712-0227Samara State Medical UniversityStatins have long occupied a central place in cardiovascular medicine, being an integral component of the prevention and treatment of atherosclerotic cardiovascular diseases (coronary heart disease and its main clinical forms, angina pectoris and myocardial infarction; transient ischemic attacks, ischemic strokes, etc.). By blocking a key enzyme of cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA-reductase), statins normalize the parameters of the lipid spectrum, primarily, the serum levels of atherogenic low-density lipoprotein cholesterol. However, in addition to the beneficial effects of statins, side effects are also characteristic, which are a significant problem in modern clinical practice due to the fact that they can cause dangerous disorders, forcing physicians to reduce dosages or completely cancel these drugs. Understanding the side effects and the mechanisms underlying their formation is important for improving the measures for the early detection, prevention and treatment of those disorders. This article discusses such side effects of statins as myotoxicity, hepatotoxicity, nephrotoxicity. The pathogenetic mechanisms underlying these toxic effects of statins are discussed. A particular attention is paid to the effect of statins on the oxidative stress, the mechanisms of oxidative damage to cellular macromolecules (lipids, proteins and DNA) and their potential role in the development of myotoxicity, hepatotoxicity and nephrotoxicity.https://journals.eco-vector.com/clinpractice/article/viewFile/108076/pdfcardiovascular diseasescholesterollow-density lipoproteinsstatinsside effectsmyotoxicityhepatotoxicitynephrotoxicityoxidative stressclinical practice |
| spellingShingle | Aleksey M. Chaulin The main side effects of statins in clinical practice Клиническая практика cardiovascular diseases cholesterol low-density lipoproteins statins side effects myotoxicity hepatotoxicity nephrotoxicity oxidative stress clinical practice |
| title | The main side effects of statins in clinical practice |
| title_full | The main side effects of statins in clinical practice |
| title_fullStr | The main side effects of statins in clinical practice |
| title_full_unstemmed | The main side effects of statins in clinical practice |
| title_short | The main side effects of statins in clinical practice |
| title_sort | main side effects of statins in clinical practice |
| topic | cardiovascular diseases cholesterol low-density lipoproteins statins side effects myotoxicity hepatotoxicity nephrotoxicity oxidative stress clinical practice |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/108076/pdf |
| work_keys_str_mv | AT alekseymchaulin themainsideeffectsofstatinsinclinicalpractice AT alekseymchaulin mainsideeffectsofstatinsinclinicalpractice |