The Molecular Mechanisms of Oleanane Aldehyde-β-enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells

The Molecular Mechanisms of Oleanane Aldehyde-β-enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells

Oleanane aldehyde-β-enone (<b>OA</b>), being the semi-synthetic derivative of the triterpenoid betulin, effectively inhibits the proliferation of HBL-100 and K562 cancer cells (IC<sub>50</sub> 0.47–0.53 µM), as well as the proliferation of their resistant subclones with high...

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Bibliographic Details
Main Authors: Natalia Moiseeva, Daria Eroshenko, Lidia Laletina, Ekaterina Rybalkina, Olga Susova, Aida Karamysheva, Irina Tolmacheva, Mikhail Nazarov, Victoria Grishko
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biology
Subjects:
triterpenoids
cytotoxicity
drug resistance
apoptosis
cell cycle
caspases
Online Access:https://www.mdpi.com/2079-7737/12/3/415

Internet

https://www.mdpi.com/2079-7737/12/3/415

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