Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice

Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice

Abstract Inflammation may contribute to multiple brain pathologies. One cause of inflammation is lipopolysaccharide/endotoxin (LPS), the levels of which are elevated in blood and/or brain during bacterial infections, gut dysfunction and neurodegenerative diseases, such as Parkinson’s disease. How in...

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Bibliographic Details
Main Authors: Stefan Milde, Francesca W. van Tartwijk, Anna Vilalta, Tamara C. Hornik, Jacob M. Dundee, Mar Puigdellívol, Guy C. Brown
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Phagocytosis
Neuroinflammation
Cell death
Parkinson’s disease
Neurodegeneration
Online Access:https://doi.org/10.1186/s12974-021-02280-2

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