Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants
Point-of-care (POC) testing has demonstrated great transformative potential in personalized medicine. In particular, patients undergoing transplantation require POC testing to ensure appropriate serum immunosuppressant levels so as to maintain adequate graft function and survival. However, no suitab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2020-01-01
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| Series: | IEEE Journal of Translational Engineering in Health and Medicine |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/8981894/ |
| _version_ | 1818331999839977472 |
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| author | Yi-Cheng Liu Christina Thantrakul Shu Kan Connie Chang-Hasnain Dong-Ru Ho |
| author_facet | Yi-Cheng Liu Christina Thantrakul Shu Kan Connie Chang-Hasnain Dong-Ru Ho |
| author_sort | Yi-Cheng Liu |
| collection | DOAJ |
| description | Point-of-care (POC) testing has demonstrated great transformative potential in personalized medicine. In particular, patients undergoing transplantation require POC testing to ensure appropriate serum immunosuppressant levels so as to maintain adequate graft function and survival. However, no suitable POC device for monitoring immunosuppressant levels is currently available. Exploiting the latest advances in metamaterials can lead to a breakthrough in POC testing. A high-contrast grating (HCG) biosensor is a low-cost, compact, simple-to-fabricate, and easy-to-operate structure. It is highly sensitive and robust in surface-based biomarker detection, which is favorable for the efficiency of a POC device. In this study, the feasibility of using an HCG as a POC sensor for therapeutic drug monitoring of immunosuppressants was evaluated. The detection efficiency of the most commonly prescribed immunosuppressive medication cyclosporine A by using this sensor was demonstrated to be comparable to those of conventional commercial kits, suggesting that the sensor has the potential to be used as a rapid detection and feedback platform for increasing drug compliance and improving new organ transplant survival. |
| first_indexed | 2024-12-13T13:28:46Z |
| format | Article |
| id | doaj.art-89135f594cbd4014be737f4556afb948 |
| institution | Directory Open Access Journal |
| issn | 2168-2372 |
| language | English |
| last_indexed | 2024-12-13T13:28:46Z |
| publishDate | 2020-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Journal of Translational Engineering in Health and Medicine |
| spelling | doaj.art-89135f594cbd4014be737f4556afb9482022-12-21T23:44:13ZengIEEEIEEE Journal of Translational Engineering in Health and Medicine2168-23722020-01-0181610.1109/JTEHM.2020.29664788981894Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of ImmunosuppressantsYi-Cheng Liu0https://orcid.org/0000-0002-3343-0336Christina Thantrakul1Shu Kan2Connie Chang-Hasnain3https://orcid.org/0000-0002-5341-6267Dong-Ru Ho4Department of Electrical Engineering and Computer Sciences, University of California–Berkeley, Berkeley, CA, USADepartment of Electrical Engineering and Computer Sciences, University of California–Berkeley, Berkeley, CA, USADepartment of Bioengineering, University of California–Berkeley, Berkeley, CA, USADepartment of Electrical Engineering and Computer Sciences, University of California–Berkeley, Berkeley, CA, USADepartment of Cardiovascular Medicine, Center for Cardiovascular Technology, Stanford University, Stanford, CA, USAPoint-of-care (POC) testing has demonstrated great transformative potential in personalized medicine. In particular, patients undergoing transplantation require POC testing to ensure appropriate serum immunosuppressant levels so as to maintain adequate graft function and survival. However, no suitable POC device for monitoring immunosuppressant levels is currently available. Exploiting the latest advances in metamaterials can lead to a breakthrough in POC testing. A high-contrast grating (HCG) biosensor is a low-cost, compact, simple-to-fabricate, and easy-to-operate structure. It is highly sensitive and robust in surface-based biomarker detection, which is favorable for the efficiency of a POC device. In this study, the feasibility of using an HCG as a POC sensor for therapeutic drug monitoring of immunosuppressants was evaluated. The detection efficiency of the most commonly prescribed immunosuppressive medication cyclosporine A by using this sensor was demonstrated to be comparable to those of conventional commercial kits, suggesting that the sensor has the potential to be used as a rapid detection and feedback platform for increasing drug compliance and improving new organ transplant survival.https://ieeexplore.ieee.org/document/8981894/Point-of-caremetamaterialstransplantationtherapeutic drug monitoring |
| spellingShingle | Yi-Cheng Liu Christina Thantrakul Shu Kan Connie Chang-Hasnain Dong-Ru Ho Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants IEEE Journal of Translational Engineering in Health and Medicine Point-of-care metamaterials transplantation therapeutic drug monitoring |
| title | Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants |
| title_full | Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants |
| title_fullStr | Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants |
| title_full_unstemmed | Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants |
| title_short | Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants |
| title_sort | feasibility of using high contrast grating as a point of care sensor for therapeutic drug monitoring of immunosuppressants |
| topic | Point-of-care metamaterials transplantation therapeutic drug monitoring |
| url | https://ieeexplore.ieee.org/document/8981894/ |
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