Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis
Systemic sclerosis is an autoimmune disorder characterized by inflammation and a progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it became clear that oxidative stress plays a key role in its pathogenesis. In this review, we highlighted the role of ROS in the v...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-07-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231718310917 |
| _version_ | 1828482867636731904 |
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| author | Ludivine Doridot Mohamed Jeljeli Charlotte Chêne Frédéric Batteux |
| author_facet | Ludivine Doridot Mohamed Jeljeli Charlotte Chêne Frédéric Batteux |
| author_sort | Ludivine Doridot |
| collection | DOAJ |
| description | Systemic sclerosis is an autoimmune disorder characterized by inflammation and a progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it became clear that oxidative stress plays a key role in its pathogenesis. In this review, we highlighted the role of ROS in the various pathological components of systemic sclerosis, namely the inflammatory, the autoimmune and the fibrotic processes. We also discussed how these pathological processes can induce ROS overproduction, thus maintaining a vicious circle. Finally, we summarized the therapeutic approaches targeting oxidative stress tested in systemic sclerosis, in cells, animal models and patients. |
| first_indexed | 2024-12-11T08:23:20Z |
| format | Article |
| id | doaj.art-89148457dbc348409ba1d58d4e6e0f51 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-11T08:23:20Z |
| publishDate | 2019-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-89148457dbc348409ba1d58d4e6e0f512022-12-22T01:14:37ZengElsevierRedox Biology2213-23172019-07-0125Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosisLudivine Doridot0Mohamed Jeljeli1Charlotte Chêne2Frédéric Batteux3Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; Corresponding author.Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; Department of Immunology, Cochin Teaching Hospital, AP-HP, 27, rue du faubourg Saint-Jacques, F75014, Paris, FranceInserm, U1016, Institut Cochin, Paris, FranceInserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; Department of Immunology, Cochin Teaching Hospital, AP-HP, 27, rue du faubourg Saint-Jacques, F75014, Paris, FranceSystemic sclerosis is an autoimmune disorder characterized by inflammation and a progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it became clear that oxidative stress plays a key role in its pathogenesis. In this review, we highlighted the role of ROS in the various pathological components of systemic sclerosis, namely the inflammatory, the autoimmune and the fibrotic processes. We also discussed how these pathological processes can induce ROS overproduction, thus maintaining a vicious circle. Finally, we summarized the therapeutic approaches targeting oxidative stress tested in systemic sclerosis, in cells, animal models and patients.http://www.sciencedirect.com/science/article/pii/S2213231718310917 |
| spellingShingle | Ludivine Doridot Mohamed Jeljeli Charlotte Chêne Frédéric Batteux Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis Redox Biology |
| title | Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis |
| title_full | Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis |
| title_fullStr | Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis |
| title_full_unstemmed | Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis |
| title_short | Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis |
| title_sort | implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation autoimmunity and fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S2213231718310917 |
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