The Immunological Capacity of Thrombocytes
Thrombocytes are numerous in the blood of aves (birds) and ichthyoids (fish). The origin of this cell type is a common hematopoietic stem cell giving rise to a cell that is active in blood coagulation, inflammatory functions, and the immune response in general. It has been well documented that throm...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/16/12950 |
| _version_ | 1797584417448787968 |
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| author | Farzana Ferdous Thomas Scott |
| author_facet | Farzana Ferdous Thomas Scott |
| author_sort | Farzana Ferdous |
| collection | DOAJ |
| description | Thrombocytes are numerous in the blood of aves (birds) and ichthyoids (fish). The origin of this cell type is a common hematopoietic stem cell giving rise to a cell that is active in blood coagulation, inflammatory functions, and the immune response in general. It has been well documented that thrombocytes can phagocytize small particles and bacteria. While phagocytosis with an associated oxidative burst has been reported for chicken thrombocytes, some questions remain as to the degradation capacity of phagosomes in ichthyoids. As innate cells, thrombocytes can be stimulated by bacterial, viral, and fungal pathogens to express altered gene expression. Furthermore, there have been observations that led researchers to state that platelets/thrombocytes are capable of serving as “professional antigen presenting cells” expressing CD40, CD80/86, MHC I, and MHC II. This indeed may be the case or, more likely at this time, provide supporting evidence that these cells aid and assist in the role of professional antigen-presenting cells to initiate adaptive immune responses. |
| first_indexed | 2024-03-10T23:51:34Z |
| format | Article |
| id | doaj.art-89159a6b0d324b2eaa33d30b6ca049cb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:51:34Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-89159a6b0d324b2eaa33d30b6ca049cb2023-11-19T01:32:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161295010.3390/ijms241612950The Immunological Capacity of ThrombocytesFarzana Ferdous0Thomas Scott1Department of Biological Sciences, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, NC 28223, USADepartment of Animal & Veterinary Sciences, Clemson University, 129 Poole Agricultural Center, Clemson, SC 29634, USAThrombocytes are numerous in the blood of aves (birds) and ichthyoids (fish). The origin of this cell type is a common hematopoietic stem cell giving rise to a cell that is active in blood coagulation, inflammatory functions, and the immune response in general. It has been well documented that thrombocytes can phagocytize small particles and bacteria. While phagocytosis with an associated oxidative burst has been reported for chicken thrombocytes, some questions remain as to the degradation capacity of phagosomes in ichthyoids. As innate cells, thrombocytes can be stimulated by bacterial, viral, and fungal pathogens to express altered gene expression. Furthermore, there have been observations that led researchers to state that platelets/thrombocytes are capable of serving as “professional antigen presenting cells” expressing CD40, CD80/86, MHC I, and MHC II. This indeed may be the case or, more likely at this time, provide supporting evidence that these cells aid and assist in the role of professional antigen-presenting cells to initiate adaptive immune responses.https://www.mdpi.com/1422-0067/24/16/12950thrombocyteinnate immune responseadaptive immune responsesantigen-presenting cell |
| spellingShingle | Farzana Ferdous Thomas Scott The Immunological Capacity of Thrombocytes International Journal of Molecular Sciences thrombocyte innate immune response adaptive immune responses antigen-presenting cell |
| title | The Immunological Capacity of Thrombocytes |
| title_full | The Immunological Capacity of Thrombocytes |
| title_fullStr | The Immunological Capacity of Thrombocytes |
| title_full_unstemmed | The Immunological Capacity of Thrombocytes |
| title_short | The Immunological Capacity of Thrombocytes |
| title_sort | immunological capacity of thrombocytes |
| topic | thrombocyte innate immune response adaptive immune responses antigen-presenting cell |
| url | https://www.mdpi.com/1422-0067/24/16/12950 |
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