Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells
Autoinflammatory diseases are a disease entity caused by the dysregulation of innate immune cells. Typical autoinflammatory diseases are monogenic disorders and often very rare. As a result, there is a relative lack of understanding of the pathogenesis, poor diagnosis and little available treatment....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/2/94 |
| _version_ | 1797416877573537792 |
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| author | Megumu K. Saito |
| author_facet | Megumu K. Saito |
| author_sort | Megumu K. Saito |
| collection | DOAJ |
| description | Autoinflammatory diseases are a disease entity caused by the dysregulation of innate immune cells. Typical autoinflammatory diseases are monogenic disorders and often very rare. As a result, there is a relative lack of understanding of the pathogenesis, poor diagnosis and little available treatment. Induced pluripotent stem (iPS) cells are a new technology being applied to in vitro disease modeling. These models are especially useful for the analysis of rare and intractable diseases including autoinflammatory diseases. In this review, I will provide a general overview of iPS cell models for autoinflammatory diseases and a brief description of the results obtained from individual reports. |
| first_indexed | 2024-03-09T06:10:33Z |
| format | Article |
| id | doaj.art-8916731872934e93907591bc46858168 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T06:10:33Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-8916731872934e93907591bc468581682023-12-03T11:59:03ZengMDPI AGChildren2227-90672021-02-01829410.3390/children8020094Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS CellsMegumu K. Saito0Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto 6068507, JapanAutoinflammatory diseases are a disease entity caused by the dysregulation of innate immune cells. Typical autoinflammatory diseases are monogenic disorders and often very rare. As a result, there is a relative lack of understanding of the pathogenesis, poor diagnosis and little available treatment. Induced pluripotent stem (iPS) cells are a new technology being applied to in vitro disease modeling. These models are especially useful for the analysis of rare and intractable diseases including autoinflammatory diseases. In this review, I will provide a general overview of iPS cell models for autoinflammatory diseases and a brief description of the results obtained from individual reports.https://www.mdpi.com/2227-9067/8/2/94iPS cellsautoinflammatory diseasesmacrophagessomatic mosaicismgenome editing |
| spellingShingle | Megumu K. Saito Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells Children iPS cells autoinflammatory diseases macrophages somatic mosaicism genome editing |
| title | Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells |
| title_full | Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells |
| title_fullStr | Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells |
| title_full_unstemmed | Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells |
| title_short | Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells |
| title_sort | elucidation of the pathogenesis of autoinflammatory diseases using ips cells |
| topic | iPS cells autoinflammatory diseases macrophages somatic mosaicism genome editing |
| url | https://www.mdpi.com/2227-9067/8/2/94 |
| work_keys_str_mv | AT megumuksaito elucidationofthepathogenesisofautoinflammatorydiseasesusingipscells |