Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India
Objective: Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity. Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any a...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2014-03-01
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| Series: | Oman Medical Journal |
| Subjects: | |
| Online Access: | http://www.omjournal.org/fultext_PDF.aspx?DetailsID=499&type=fultext |
| _version_ | 1818766270291509248 |
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| author | Apurva Srivastava Balraj Mittal Jai Prakash Varun Shanker Narain S.M. Natu Neena Srivastava |
| author_facet | Apurva Srivastava Balraj Mittal Jai Prakash Varun Shanker Narain S.M. Natu Neena Srivastava |
| author_sort | Apurva Srivastava |
| collection | DOAJ |
| description | Objective: Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity. Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any association with obesity in North Indian subjects.
Methods: The variants were investigated for association in 300 individuals with BMI ≥30 kg/m2 and 300 healthy non-obese individuals BMI <30 kg/m2. The genotyping were analyzed by Taqman probes. The statistical analysis was performed by the SPSS software, ver.19 and p≤0.05 was considered statistically significant.
Results: The genotypes of MC4R rs17782313 and POMC rs1042571 were significantly associated with obesity (C), (p=0.02; OR=1.7 and p=0.01; OR=1.6, respectively); however, MC4Rrs17700633 (p=0.001; OR=0.55) was associated with low risk. In addition, AGRPrs3412352 (p=0.93; OR=0.96) showed no association with obesity (BMI ≥30 kg/m2) in North Indian subjects.
Conclusion: This study provides the report about the significant association of MC4R (rs17782313) and POMC (rs1042571) with morbid obesity (BMI ≥30 kg/m2), but MC4R (rs17700633) and AGRP (rs34123523) did not show any association with obesity in the studied North Indian population. |
| first_indexed | 2024-12-18T08:31:19Z |
| format | Article |
| id | doaj.art-89175cfff5c048609222ed761c3ee16c |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-18T08:31:19Z |
| publishDate | 2014-03-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-89175cfff5c048609222ed761c3ee16c2022-12-21T21:14:27ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042014-03-0129211411810.5001/omj.2014.28Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern IndiaApurva Srivastava0Balraj Mittal1Jai Prakash2Varun Shanker Narain3S.M. Natu4Neena Srivastava5Department of Physiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh, India 226014.Department of Pediatrics, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.Department of Cardiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.Department of Pathology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.Department of Physiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.Objective: Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity. Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any association with obesity in North Indian subjects. Methods: The variants were investigated for association in 300 individuals with BMI ≥30 kg/m2 and 300 healthy non-obese individuals BMI <30 kg/m2. The genotyping were analyzed by Taqman probes. The statistical analysis was performed by the SPSS software, ver.19 and p≤0.05 was considered statistically significant. Results: The genotypes of MC4R rs17782313 and POMC rs1042571 were significantly associated with obesity (C), (p=0.02; OR=1.7 and p=0.01; OR=1.6, respectively); however, MC4Rrs17700633 (p=0.001; OR=0.55) was associated with low risk. In addition, AGRPrs3412352 (p=0.93; OR=0.96) showed no association with obesity (BMI ≥30 kg/m2) in North Indian subjects. Conclusion: This study provides the report about the significant association of MC4R (rs17782313) and POMC (rs1042571) with morbid obesity (BMI ≥30 kg/m2), but MC4R (rs17700633) and AGRP (rs34123523) did not show any association with obesity in the studied North Indian population.http://www.omjournal.org/fultext_PDF.aspx?DetailsID=499&type=fultextObesityGenetic variantsGenotypePhenotypeMC4RAGRPPOMC |
| spellingShingle | Apurva Srivastava Balraj Mittal Jai Prakash Varun Shanker Narain S.M. Natu Neena Srivastava Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India Oman Medical Journal Obesity Genetic variants Genotype Phenotype MC4R AGRP POMC |
| title | Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India |
| title_full | Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India |
| title_fullStr | Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India |
| title_full_unstemmed | Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India |
| title_short | Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India |
| title_sort | evaluation of mc4r rs17782313 rs17700633 agrp rs3412352 and pomc rs1042571 polymorphisms with obesity in northern india |
| topic | Obesity Genetic variants Genotype Phenotype MC4R AGRP POMC |
| url | http://www.omjournal.org/fultext_PDF.aspx?DetailsID=499&type=fultext |
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