COVID-19 and the Risk of Diabetes: A Systematic Review Article
Background: COVID-19 pandemic associates with many acute and long-term effects. Hyperglycemia and diabetes are among the common comorbidities that negatively affect the outcome of COVID-19 patients. Many studies report an increase in the incidence of new-onset diabetes and diabetic ketoacidosis duri...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-07-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
| Subjects: | |
| Online Access: | https://apjmt.mums.ac.ir/article_22804_a21d24e958e361e40ae9279647ac2b31.pdf |
| _version_ | 1797744211352616960 |
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| author | Noor Mohamed-Jawad Zainab Abdulnabi |
| author_facet | Noor Mohamed-Jawad Zainab Abdulnabi |
| author_sort | Noor Mohamed-Jawad |
| collection | DOAJ |
| description | Background: COVID-19 pandemic associates with many acute and long-term effects. Hyperglycemia and diabetes are among the common comorbidities that negatively affect the outcome of COVID-19 patients. Many studies report an increase in the incidence of new-onset diabetes and diabetic ketoacidosis during the pandemic of COVID-19. Aim of the Study: This review article aimed to study the bidirectional relationship between diabetes and COVID-19 and understand the possible underlying mechanisms predisposed to diabetes in patients with COVID-19. Methods: The present work performs an online literature search on databases from PubMed, Google Scholar, Scopus, ResearchGate, and Web of Science. The search includes publications on SARS-CoV-2 or COVID-19, hyperglycemia, diabetes, and diabetic ketoacidosis. Results: There is a slight increase in the incidence of hyperglycemia and new-onset diabetes during or post COVID-19 infections. Among the proposed mechanisms of that increase are the direct and indirect effects of SARS-CoV-2 on Beta cells of the pancreas. These effects arise from viral-mediated inflammatory and immunological effects on Beta cells. Stress hyperglycemia, corticosteroid administration, obesity, and preexisting diabetes are important aggravating factors for developing diabetes in COVID-19 patients. Conclusion: The long-term follow-up is mandatory to determine the outcome of patients, who develop new-onset diabetes after COVID-19 infection. |
| first_indexed | 2024-03-12T15:06:29Z |
| format | Article |
| id | doaj.art-8917d043f5d444a2bda463f04816b844 |
| institution | Directory Open Access Journal |
| issn | 2322-2611 2322-4320 |
| language | English |
| last_indexed | 2024-03-12T15:06:29Z |
| publishDate | 2023-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj.art-8917d043f5d444a2bda463f04816b8442023-08-12T14:38:01ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202023-07-01122667110.22038/apjmt.2023.2280422804COVID-19 and the Risk of Diabetes: A Systematic Review ArticleNoor Mohamed-Jawad0Zainab Abdulnabi1Department of Clinical Pharmacy, College of Pharmacy, University of Basrah, Basra, Iraq.Department of pharmacology, College of Pharmacy, University of Basrah, Basra, Iraq.Background: COVID-19 pandemic associates with many acute and long-term effects. Hyperglycemia and diabetes are among the common comorbidities that negatively affect the outcome of COVID-19 patients. Many studies report an increase in the incidence of new-onset diabetes and diabetic ketoacidosis during the pandemic of COVID-19. Aim of the Study: This review article aimed to study the bidirectional relationship between diabetes and COVID-19 and understand the possible underlying mechanisms predisposed to diabetes in patients with COVID-19. Methods: The present work performs an online literature search on databases from PubMed, Google Scholar, Scopus, ResearchGate, and Web of Science. The search includes publications on SARS-CoV-2 or COVID-19, hyperglycemia, diabetes, and diabetic ketoacidosis. Results: There is a slight increase in the incidence of hyperglycemia and new-onset diabetes during or post COVID-19 infections. Among the proposed mechanisms of that increase are the direct and indirect effects of SARS-CoV-2 on Beta cells of the pancreas. These effects arise from viral-mediated inflammatory and immunological effects on Beta cells. Stress hyperglycemia, corticosteroid administration, obesity, and preexisting diabetes are important aggravating factors for developing diabetes in COVID-19 patients. Conclusion: The long-term follow-up is mandatory to determine the outcome of patients, who develop new-onset diabetes after COVID-19 infection.https://apjmt.mums.ac.ir/article_22804_a21d24e958e361e40ae9279647ac2b31.pdfcovid-19diabetesdiabetic ketoacidosishyperglycemia |
| spellingShingle | Noor Mohamed-Jawad Zainab Abdulnabi COVID-19 and the Risk of Diabetes: A Systematic Review Article Asia Pacific Journal of Medical Toxicology covid-19 diabetes diabetic ketoacidosis hyperglycemia |
| title | COVID-19 and the Risk of Diabetes: A Systematic Review Article |
| title_full | COVID-19 and the Risk of Diabetes: A Systematic Review Article |
| title_fullStr | COVID-19 and the Risk of Diabetes: A Systematic Review Article |
| title_full_unstemmed | COVID-19 and the Risk of Diabetes: A Systematic Review Article |
| title_short | COVID-19 and the Risk of Diabetes: A Systematic Review Article |
| title_sort | covid 19 and the risk of diabetes a systematic review article |
| topic | covid-19 diabetes diabetic ketoacidosis hyperglycemia |
| url | https://apjmt.mums.ac.ir/article_22804_a21d24e958e361e40ae9279647ac2b31.pdf |
| work_keys_str_mv | AT noormohamedjawad covid19andtheriskofdiabetesasystematicreviewarticle AT zainababdulnabi covid19andtheriskofdiabetesasystematicreviewarticle |