Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use
Tenofovir disoproxil fumarate (TDF) is used worldwide to treat and prevent Human Immunodeficiency Virus (HIV) infection. Fanconi syndrome is a complication of TDF use and is characterized by inadequate reabsorption of glucose, phosphate and protein in the proximal tubule of the kidney which may even...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Infectious Disease Reports |
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| Online Access: | https://www.mdpi.com/2036-7449/13/2/44 |
| _version_ | 1797532940203196416 |
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| author | Mana Rao Liam Dadey Thomas Glowa Peter Veldkamp |
| author_facet | Mana Rao Liam Dadey Thomas Glowa Peter Veldkamp |
| author_sort | Mana Rao |
| collection | DOAJ |
| description | Tenofovir disoproxil fumarate (TDF) is used worldwide to treat and prevent Human Immunodeficiency Virus (HIV) infection. Fanconi syndrome is a complication of TDF use and is characterized by inadequate reabsorption of glucose, phosphate and protein in the proximal tubule of the kidney which may eventually lead to osteomalacia manifested by symptoms of pain, muscular weakness and difficulty ambulating. We present a patient with severe osteomalacia due to progressive and unrecognized Fanconi’s syndrome, who responded rapidly to TDF withdrawal, oral phosphate repletion and calcitriol. With the widespread use of TDF-containing antiviral regimens, it is critically important that physicians adhere to screening recommendations to detect early Fanconi syndrome, and recognize symptoms of osteomalacia as a serious complication. |
| first_indexed | 2024-03-10T11:07:29Z |
| format | Article |
| id | doaj.art-891845788b6d4fe0a00b76dd38ed9e7f |
| institution | Directory Open Access Journal |
| issn | 2036-7449 |
| language | English |
| last_indexed | 2024-03-10T11:07:29Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-891845788b6d4fe0a00b76dd38ed9e7f2023-11-21T21:03:11ZengMDPI AGInfectious Disease Reports2036-74492021-05-0113244845310.3390/idr13020044Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir UseMana Rao0Liam Dadey1Thomas Glowa2Peter Veldkamp3Essen Medical Associates Bronx, New York, NY 10453, USAParkview Health, Fort Wayne, IN 46805, USADivision of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USADivision of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USATenofovir disoproxil fumarate (TDF) is used worldwide to treat and prevent Human Immunodeficiency Virus (HIV) infection. Fanconi syndrome is a complication of TDF use and is characterized by inadequate reabsorption of glucose, phosphate and protein in the proximal tubule of the kidney which may eventually lead to osteomalacia manifested by symptoms of pain, muscular weakness and difficulty ambulating. We present a patient with severe osteomalacia due to progressive and unrecognized Fanconi’s syndrome, who responded rapidly to TDF withdrawal, oral phosphate repletion and calcitriol. With the widespread use of TDF-containing antiviral regimens, it is critically important that physicians adhere to screening recommendations to detect early Fanconi syndrome, and recognize symptoms of osteomalacia as a serious complication.https://www.mdpi.com/2036-7449/13/2/44tenofovirFanconi syndromehypophosphatemic osteomalaciaHIVadverse event |
| spellingShingle | Mana Rao Liam Dadey Thomas Glowa Peter Veldkamp Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use Infectious Disease Reports tenofovir Fanconi syndrome hypophosphatemic osteomalacia HIV adverse event |
| title | Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use |
| title_full | Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use |
| title_fullStr | Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use |
| title_full_unstemmed | Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use |
| title_short | Fanconi Syndrome Leading to Hypophosphatemic Osteomalacia Related to Tenofovir Use |
| title_sort | fanconi syndrome leading to hypophosphatemic osteomalacia related to tenofovir use |
| topic | tenofovir Fanconi syndrome hypophosphatemic osteomalacia HIV adverse event |
| url | https://www.mdpi.com/2036-7449/13/2/44 |
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