Increased serum adenosine deaminase activity in patients with adult-onset Still's disease
Abstract Background Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology, lacking specific diagnosis and disease activity evaluation indicators. This study will analyze the activity and clinical significance of Adenosine deaminase (ADA) in AOSD patients. Met...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-022-00477-5 |
| _version_ | 1819349918903435264 |
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| author | Zhiye Xu Linyu Geng LiLi Guo Hongyan Song Jie Pan Han Shen Sen Wang |
| author_facet | Zhiye Xu Linyu Geng LiLi Guo Hongyan Song Jie Pan Han Shen Sen Wang |
| author_sort | Zhiye Xu |
| collection | DOAJ |
| description | Abstract Background Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology, lacking specific diagnosis and disease activity evaluation indicators. This study will analyze the activity and clinical significance of Adenosine deaminase (ADA) in AOSD patients. Methods Totally 53 AOSD patients, 60 patients with other autoimmune diseases including systemic lupus erythematosus (SLE), sjogren syndrome (SS) and rheumatoid arthritis (RA), as well as 60 healthy subjects were included in this study. AOSD activity was determined by Pouchot score. We analyzed the correlation between ADA activity and clinical parameters. In addition, the correlation between ADA activity and disease activity score was also analyzed. Results This study showed that the activity of ADA in AOSD patients was significantly higher than that of healthy controls, SLE, SS and RA patient groups (p < 0.0001). The ADA activity of AOSD patients decreased significantly after systemic treatment (p < 0.0001). Correlation analysis showed that ADA activity was positively correlated with ALT(r = 0.54, p < 0.0001), AST (r = 0.82, p < 0.0001) and serum ferritin (r = 0.67, p < 0.001). ADA activity was negatively correlated with white blood cell (r = − 0.42, p = 0.002) and platelet counts (r = − 0.44, p = 0.001). We also found a significant positive correlation between the activity of ADA and Pouchot score in AOSD patients (r = 0.51, p = 0.001). Receiver operating characteristic (ROC) curve analysis showed that ADA activity had a sensitivity of 93.3%, and a specificity of 83% for the diagnosis of AOSD, with an area under the curve of 0.93. Conclusion This study showed that serum ADA activity can be used as a potential biomarker for AOSD diagnosis and disease activity assessment. |
| first_indexed | 2024-12-24T19:08:10Z |
| format | Article |
| id | doaj.art-8919372dbffe4260867a04aec971324d |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-24T19:08:10Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-8919372dbffe4260867a04aec971324d2022-12-21T16:43:04ZengBMCBMC Immunology1471-21722022-01-012311810.1186/s12865-022-00477-5Increased serum adenosine deaminase activity in patients with adult-onset Still's diseaseZhiye Xu0Linyu Geng1LiLi Guo2Hongyan Song3Jie Pan4Han Shen5Sen Wang6Department of Clinical Laboratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolAbstract Background Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology, lacking specific diagnosis and disease activity evaluation indicators. This study will analyze the activity and clinical significance of Adenosine deaminase (ADA) in AOSD patients. Methods Totally 53 AOSD patients, 60 patients with other autoimmune diseases including systemic lupus erythematosus (SLE), sjogren syndrome (SS) and rheumatoid arthritis (RA), as well as 60 healthy subjects were included in this study. AOSD activity was determined by Pouchot score. We analyzed the correlation between ADA activity and clinical parameters. In addition, the correlation between ADA activity and disease activity score was also analyzed. Results This study showed that the activity of ADA in AOSD patients was significantly higher than that of healthy controls, SLE, SS and RA patient groups (p < 0.0001). The ADA activity of AOSD patients decreased significantly after systemic treatment (p < 0.0001). Correlation analysis showed that ADA activity was positively correlated with ALT(r = 0.54, p < 0.0001), AST (r = 0.82, p < 0.0001) and serum ferritin (r = 0.67, p < 0.001). ADA activity was negatively correlated with white blood cell (r = − 0.42, p = 0.002) and platelet counts (r = − 0.44, p = 0.001). We also found a significant positive correlation between the activity of ADA and Pouchot score in AOSD patients (r = 0.51, p = 0.001). Receiver operating characteristic (ROC) curve analysis showed that ADA activity had a sensitivity of 93.3%, and a specificity of 83% for the diagnosis of AOSD, with an area under the curve of 0.93. Conclusion This study showed that serum ADA activity can be used as a potential biomarker for AOSD diagnosis and disease activity assessment.https://doi.org/10.1186/s12865-022-00477-5AOSDADADiagnosisDisease activity |
| spellingShingle | Zhiye Xu Linyu Geng LiLi Guo Hongyan Song Jie Pan Han Shen Sen Wang Increased serum adenosine deaminase activity in patients with adult-onset Still's disease BMC Immunology AOSD ADA Diagnosis Disease activity |
| title | Increased serum adenosine deaminase activity in patients with adult-onset Still's disease |
| title_full | Increased serum adenosine deaminase activity in patients with adult-onset Still's disease |
| title_fullStr | Increased serum adenosine deaminase activity in patients with adult-onset Still's disease |
| title_full_unstemmed | Increased serum adenosine deaminase activity in patients with adult-onset Still's disease |
| title_short | Increased serum adenosine deaminase activity in patients with adult-onset Still's disease |
| title_sort | increased serum adenosine deaminase activity in patients with adult onset still s disease |
| topic | AOSD ADA Diagnosis Disease activity |
| url | https://doi.org/10.1186/s12865-022-00477-5 |
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