The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
Currently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA tra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/9324 |
| _version_ | 1797409752547852288 |
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| author | Fatimat Kipkeeva Tatyana Muzaffarova Alexandra Korotaeva Danzan Mansorunov Pavel Apanovich Maxim Nikulin Olga Malikhova Ivan Stilidi Alexander Karpukhin |
| author_facet | Fatimat Kipkeeva Tatyana Muzaffarova Alexandra Korotaeva Danzan Mansorunov Pavel Apanovich Maxim Nikulin Olga Malikhova Ivan Stilidi Alexander Karpukhin |
| author_sort | Fatimat Kipkeeva |
| collection | DOAJ |
| description | Currently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA translation. An important feature of miRNA is its ability to affect the expression of several genes simultaneously, which corresponds to the trend toward the use of combination therapy. The article provides a list of miRNAs acting simultaneously on several ICs and miRNAs that, in addition to IC, can regulate the expression of targeted therapy genes. There is dependence of miRNA interactions with IC genes on the type of cancer. The analysis of the accumulated data demonstrates that only about 14% (95% CI: 9.8–20.1%) of the studied miRNAs regulate the expression of specific IC in more than one type of cancer. That is, there is tumor specificity in the miRNA action on ICs. A number of miRNAs demonstrated high efficiency in vitro and in vivo. This indicates the potential of miRNAs as promising agents for cancer immunotherapy. Additional studies of the miRNA–gene interaction features and the search for an optimal miRNA mimic structure are necessary. |
| first_indexed | 2024-03-09T04:19:09Z |
| format | Article |
| id | doaj.art-891a8d9d918c4f00b39d0d93dab6e298 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:19:09Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-891a8d9d918c4f00b39d0d93dab6e2982023-12-03T13:49:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316932410.3390/ijms23169324The Features of Immune Checkpoint Gene Regulation by microRNA in CancerFatimat Kipkeeva0Tatyana Muzaffarova1Alexandra Korotaeva2Danzan Mansorunov3Pavel Apanovich4Maxim Nikulin5Olga Malikhova6Ivan Stilidi7Alexander Karpukhin8Research Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115478 Moscow, RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115478 Moscow, RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115478 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaCurrently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA translation. An important feature of miRNA is its ability to affect the expression of several genes simultaneously, which corresponds to the trend toward the use of combination therapy. The article provides a list of miRNAs acting simultaneously on several ICs and miRNAs that, in addition to IC, can regulate the expression of targeted therapy genes. There is dependence of miRNA interactions with IC genes on the type of cancer. The analysis of the accumulated data demonstrates that only about 14% (95% CI: 9.8–20.1%) of the studied miRNAs regulate the expression of specific IC in more than one type of cancer. That is, there is tumor specificity in the miRNA action on ICs. A number of miRNAs demonstrated high efficiency in vitro and in vivo. This indicates the potential of miRNAs as promising agents for cancer immunotherapy. Additional studies of the miRNA–gene interaction features and the search for an optimal miRNA mimic structure are necessary.https://www.mdpi.com/1422-0067/23/16/9324microRNAimmune checkpointimmunotherapy |
| spellingShingle | Fatimat Kipkeeva Tatyana Muzaffarova Alexandra Korotaeva Danzan Mansorunov Pavel Apanovich Maxim Nikulin Olga Malikhova Ivan Stilidi Alexander Karpukhin The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer International Journal of Molecular Sciences microRNA immune checkpoint immunotherapy |
| title | The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer |
| title_full | The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer |
| title_fullStr | The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer |
| title_full_unstemmed | The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer |
| title_short | The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer |
| title_sort | features of immune checkpoint gene regulation by microrna in cancer |
| topic | microRNA immune checkpoint immunotherapy |
| url | https://www.mdpi.com/1422-0067/23/16/9324 |
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