One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah
From July–November 2020, mink (<i>Neogale vison</i>) on 12 Utah farms experienced an increase in mortality rates due to confirmed SARS-CoV-2 infection. We conducted epidemiologic investigations on six farms to identify the source of virus introduction, track cross-species transmission, a...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/96 |
| _version_ | 1797436488471805952 |
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| author | Caitlin M. Cossaboom Natalie M. Wendling Nathaniel M. Lewis Hannah Rettler Robert R. Harvey Brian R. Amman Jonathan S. Towner Jessica R. Spengler Robert Erickson Cindy Burnett Erin L. Young Kelly Oakeson Ann Carpenter Markus H. Kainulainen Payel Chatterjee Mike Flint Anna Uehara Yan Li Jing Zhang Anna Kelleher Brian Lynch Adam C. Retchless Suxiang Tong Ausaf Ahmad Paige Bunkley Claire Godino Owen Herzegh Jan Drobeniuc Jane Rooney Dean Taylor Casey Barton Behravesh |
| author_facet | Caitlin M. Cossaboom Natalie M. Wendling Nathaniel M. Lewis Hannah Rettler Robert R. Harvey Brian R. Amman Jonathan S. Towner Jessica R. Spengler Robert Erickson Cindy Burnett Erin L. Young Kelly Oakeson Ann Carpenter Markus H. Kainulainen Payel Chatterjee Mike Flint Anna Uehara Yan Li Jing Zhang Anna Kelleher Brian Lynch Adam C. Retchless Suxiang Tong Ausaf Ahmad Paige Bunkley Claire Godino Owen Herzegh Jan Drobeniuc Jane Rooney Dean Taylor Casey Barton Behravesh |
| author_sort | Caitlin M. Cossaboom |
| collection | DOAJ |
| description | From July–November 2020, mink (<i>Neogale vison</i>) on 12 Utah farms experienced an increase in mortality rates due to confirmed SARS-CoV-2 infection. We conducted epidemiologic investigations on six farms to identify the source of virus introduction, track cross-species transmission, and assess viral evolution. Interviews were conducted and specimens were collected from persons living or working on participating farms and from multiple animal species. Swabs and sera were tested by SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and serological assays, respectively. Whole genome sequencing was attempted for specimens with cycle threshold values <30. Evidence of SARS-CoV-2 infection was detected by rRT-PCR or serology in ≥1 person, farmed mink, dog, and/or feral cat on each farm. Sequence analysis showed high similarity between mink and human sequences on corresponding farms. On farms sampled at multiple time points, mink tested rRT-PCR positive up to 16 weeks post-onset of increased mortality. Workers likely introduced SARS-CoV-2 to mink, and mink transmitted SARS-CoV-2 to other animal species; mink-to-human transmission was not identified. Our findings provide critical evidence to support interventions to prevent and manage SARS-CoV-2 in people and animals on mink farms and emphasizes the importance of a One Health approach to address emerging zoonoses. |
| first_indexed | 2024-03-09T11:02:19Z |
| format | Article |
| id | doaj.art-891c6ea8d55c4c50b2d1eac30e649bdf |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:02:19Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-891c6ea8d55c4c50b2d1eac30e649bdf2023-12-01T01:09:49ZengMDPI AGViruses1999-49152022-12-011519610.3390/v15010096One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in UtahCaitlin M. Cossaboom0Natalie M. Wendling1Nathaniel M. Lewis2Hannah Rettler3Robert R. Harvey4Brian R. Amman5Jonathan S. Towner6Jessica R. Spengler7Robert Erickson8Cindy Burnett9Erin L. Young10Kelly Oakeson11Ann Carpenter12Markus H. Kainulainen13Payel Chatterjee14Mike Flint15Anna Uehara16Yan Li17Jing Zhang18Anna Kelleher19Brian Lynch20Adam C. Retchless21Suxiang Tong22Ausaf Ahmad23Paige Bunkley24Claire Godino25Owen Herzegh26Jan Drobeniuc27Jane Rooney28Dean Taylor29Casey Barton Behravesh30National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAUtah Department of Health and Human Services, Salt Lake City, UT 84116, USAUtah Department of Health and Human Services, Salt Lake City, UT 84116, USACenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAUtah Department of Agriculture and Food, Salt Lake City, UT 84129, USAUtah Department of Health and Human Services, Salt Lake City, UT 84116, USAUtah Public Health Laboratory, Utah Department of Health and Human Services, Salt Lake City, UT 84129, USAUtah Public Health Laboratory, Utah Department of Health and Human Services, Salt Lake City, UT 84129, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USACDC National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAUnited States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, Fort Collins, CO 80526, USAUtah Department of Agriculture and Food, Salt Lake City, UT 84129, USANational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAFrom July–November 2020, mink (<i>Neogale vison</i>) on 12 Utah farms experienced an increase in mortality rates due to confirmed SARS-CoV-2 infection. We conducted epidemiologic investigations on six farms to identify the source of virus introduction, track cross-species transmission, and assess viral evolution. Interviews were conducted and specimens were collected from persons living or working on participating farms and from multiple animal species. Swabs and sera were tested by SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and serological assays, respectively. Whole genome sequencing was attempted for specimens with cycle threshold values <30. Evidence of SARS-CoV-2 infection was detected by rRT-PCR or serology in ≥1 person, farmed mink, dog, and/or feral cat on each farm. Sequence analysis showed high similarity between mink and human sequences on corresponding farms. On farms sampled at multiple time points, mink tested rRT-PCR positive up to 16 weeks post-onset of increased mortality. Workers likely introduced SARS-CoV-2 to mink, and mink transmitted SARS-CoV-2 to other animal species; mink-to-human transmission was not identified. Our findings provide critical evidence to support interventions to prevent and manage SARS-CoV-2 in people and animals on mink farms and emphasizes the importance of a One Health approach to address emerging zoonoses.https://www.mdpi.com/1999-4915/15/1/96SARS-CoV-2coronavirusCOVID-19zoonotic transmissionanimalsmink |
| spellingShingle | Caitlin M. Cossaboom Natalie M. Wendling Nathaniel M. Lewis Hannah Rettler Robert R. Harvey Brian R. Amman Jonathan S. Towner Jessica R. Spengler Robert Erickson Cindy Burnett Erin L. Young Kelly Oakeson Ann Carpenter Markus H. Kainulainen Payel Chatterjee Mike Flint Anna Uehara Yan Li Jing Zhang Anna Kelleher Brian Lynch Adam C. Retchless Suxiang Tong Ausaf Ahmad Paige Bunkley Claire Godino Owen Herzegh Jan Drobeniuc Jane Rooney Dean Taylor Casey Barton Behravesh One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah Viruses SARS-CoV-2 coronavirus COVID-19 zoonotic transmission animals mink |
| title | One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah |
| title_full | One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah |
| title_fullStr | One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah |
| title_full_unstemmed | One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah |
| title_short | One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah |
| title_sort | one health investigation of sars cov 2 in people and animals on multiple mink farms in utah |
| topic | SARS-CoV-2 coronavirus COVID-19 zoonotic transmission animals mink |
| url | https://www.mdpi.com/1999-4915/15/1/96 |
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