S-Ketamine Oral Thin Film—Part 1: Population Pharmacokinetics of S-Ketamine, S-Norketamine and S-Hydroxynorketamine

S-Ketamine Oral Thin Film—Part 1: Population Pharmacokinetics of S-Ketamine, S-Norketamine and S-Hydroxynorketamine

Ketamine is administered predominantly via the intravenous route for the various indications, including anesthesia, pain relief and treatment of depression. Here we report on the pharmacokinetics of sublingual and buccal fast-dissolving oral-thin-films that contain 50 mg of S-ketamine in a populatio...

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Bibliographic Details
Main Authors: Pieter Simons, Erik Olofsen, Monique van Velzen, Maarten van Lemmen, René Mooren, Tom van Dasselaar, Patrick Mohr, Florian Hammes, Rutger van der Schrier, Marieke Niesters, Albert Dahan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pain Research
Subjects:
ketamine
modeling
pharmacokinetics
neuropathic pain
oral thin film
S-ketamine
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2022.946486/full

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