The social shaping of a diagnosis in Next Generation Sequencing
Although Next Generation Sequencing (NGS) has increased our ability to test and diagnose, its results are often not clear-cut and require a complex interpretation and negotiation process by both healthcare professionals and patients involved. In this paper, we explore how diagnoses identified throug...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2021-10-01
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Series: | New Genetics and Society |
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Online Access: | http://dx.doi.org/10.1080/14636778.2020.1853514 |
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author | Janneke M.L. Kuiper Pascal Borry Danya F. Vears Ine Van Hoyweghen |
author_facet | Janneke M.L. Kuiper Pascal Borry Danya F. Vears Ine Van Hoyweghen |
author_sort | Janneke M.L. Kuiper |
collection | DOAJ |
description | Although Next Generation Sequencing (NGS) has increased our ability to test and diagnose, its results are often not clear-cut and require a complex interpretation and negotiation process by both healthcare professionals and patients involved. In this paper, we explore how diagnoses identified through NGS are socially shaped under influence of the broader social context. Using an analytical framework stemming from the sociology of health and illness and science and technology studies, with a focus on the construction of diagnosis and the role of uncertainty in medicine, we analyze the existing corpus of literature on NGS diagnostic practices. We show how in this early implementation phase of NGS, in which standardization efforts are not yet solidified, the boundary struggles around diagnoses obtained through NGS are particularly visible. We discuss the different steps in the diagnosis shaping process and what it subsequently entails to give and a receive a diagnosis using NGS. |
first_indexed | 2024-03-11T23:41:47Z |
format | Article |
id | doaj.art-891dd941b3b54ed2b30864fba434bb17 |
institution | Directory Open Access Journal |
issn | 1463-6778 1469-9915 |
language | English |
last_indexed | 2024-03-11T23:41:47Z |
publishDate | 2021-10-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | New Genetics and Society |
spelling | doaj.art-891dd941b3b54ed2b30864fba434bb172023-09-19T15:22:18ZengTaylor & Francis GroupNew Genetics and Society1463-67781469-99152021-10-0140442544810.1080/14636778.2020.18535141853514The social shaping of a diagnosis in Next Generation SequencingJanneke M.L. Kuiper0Pascal Borry1Danya F. Vears2Ine Van Hoyweghen3Life Sciences and Society Lab, Centre for Sociological Research, KU LeuvenCentre for Biomedical Ethics and Law, Department of Public Health and Primary Care, KU LeuvenMelbourne Law School, University of MelbourneLife Sciences and Society Lab, Centre for Sociological Research, KU LeuvenAlthough Next Generation Sequencing (NGS) has increased our ability to test and diagnose, its results are often not clear-cut and require a complex interpretation and negotiation process by both healthcare professionals and patients involved. In this paper, we explore how diagnoses identified through NGS are socially shaped under influence of the broader social context. Using an analytical framework stemming from the sociology of health and illness and science and technology studies, with a focus on the construction of diagnosis and the role of uncertainty in medicine, we analyze the existing corpus of literature on NGS diagnostic practices. We show how in this early implementation phase of NGS, in which standardization efforts are not yet solidified, the boundary struggles around diagnoses obtained through NGS are particularly visible. We discuss the different steps in the diagnosis shaping process and what it subsequently entails to give and a receive a diagnosis using NGS.http://dx.doi.org/10.1080/14636778.2020.1853514diagnosisnext generation sequencinguncertaintygenomics |
spellingShingle | Janneke M.L. Kuiper Pascal Borry Danya F. Vears Ine Van Hoyweghen The social shaping of a diagnosis in Next Generation Sequencing New Genetics and Society diagnosis next generation sequencing uncertainty genomics |
title | The social shaping of a diagnosis in Next Generation Sequencing |
title_full | The social shaping of a diagnosis in Next Generation Sequencing |
title_fullStr | The social shaping of a diagnosis in Next Generation Sequencing |
title_full_unstemmed | The social shaping of a diagnosis in Next Generation Sequencing |
title_short | The social shaping of a diagnosis in Next Generation Sequencing |
title_sort | social shaping of a diagnosis in next generation sequencing |
topic | diagnosis next generation sequencing uncertainty genomics |
url | http://dx.doi.org/10.1080/14636778.2020.1853514 |
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