Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppress...

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Bibliographic Details
Main Authors: Mithunah Krishnamoorthy, Lara Gerhardt, Saman Maleki Vareki
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
immunotherapy
MDSCs
T-cells
anti-PD-1
cancer
tumors
Online Access:https://www.mdpi.com/2073-4409/10/5/1170

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