Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome
Gut microbiome (GM) is closely related to the overall health status for the human being. The dysfunction of microbiome can lead to many diseases such as inflammation, cancer and neurodegenerative disease. Therefore, it's of great importance to develop effective strategy to regulate GM. Gut lume...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2022-12-01
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| Series: | Journal of Future Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772566922000568 |
| _version_ | 1798005553682710528 |
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| author | Junyu Liu Xiaobin Li Xiaopeng Zhang Runming Wang Sanyang Han Peiwu Qin Xin-Hui Xing Canyang Zhang |
| author_facet | Junyu Liu Xiaobin Li Xiaopeng Zhang Runming Wang Sanyang Han Peiwu Qin Xin-Hui Xing Canyang Zhang |
| author_sort | Junyu Liu |
| collection | DOAJ |
| description | Gut microbiome (GM) is closely related to the overall health status for the human being. The dysfunction of microbiome can lead to many diseases such as inflammation, cancer and neurodegenerative disease. Therefore, it's of great importance to develop effective strategy to regulate GM. Gut lumen-targeted oral delivery system (GLT-ODS) has been extensively investigated and widely used in food science and engineering in these years, due to the targeted delivery property, controlled release profile, high biocompatibility and enhanced bioavailability of cargos. Herein, we comprehensively summarized the current advances in GLT-ODS for bioactive agent. Specifically, we systematically summarize the GLT-ODS for pre-agents (prebiotics and probiotics) and anti-agents (antibiotics and bacteriophages) according to the type of cargos. Through in-depth discussion of representative researches, we refined the limitations of existing research in carrier material and target selection, and drew a blueprint for the future technological research and development. We believe that GLT-ODS will become a safe, efficient, simple and precise GM management strategy for improvement of health and shine in the development of precision food and pharmaceutical engineering in future. |
| first_indexed | 2024-04-11T12:41:02Z |
| format | Article |
| id | doaj.art-8924c868dd7a46ecab4fce4c6b5e9b6f |
| institution | Directory Open Access Journal |
| issn | 2772-5669 |
| language | English |
| last_indexed | 2024-04-11T12:41:02Z |
| publishDate | 2022-12-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Journal of Future Foods |
| spelling | doaj.art-8924c868dd7a46ecab4fce4c6b5e9b6f2022-12-22T04:23:30ZengKeAi Communications Co. Ltd.Journal of Future Foods2772-56692022-12-0124307325Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiomeJunyu Liu0Xiaobin Li1Xiaopeng Zhang2Runming Wang3Sanyang Han4Peiwu Qin5Xin-Hui Xing6Canyang Zhang7Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China; Corresponding author at: Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China; Institute of Biochemical Engineering, Department of Chemical Engineering, Key Laboratory for Industrial Biocatalysis, Ministry of Education, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518055, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518055, China; Corresponding author at: Tsinghua Shenzhen International Graduate School, Shenzhen 518055, ChinaGut microbiome (GM) is closely related to the overall health status for the human being. The dysfunction of microbiome can lead to many diseases such as inflammation, cancer and neurodegenerative disease. Therefore, it's of great importance to develop effective strategy to regulate GM. Gut lumen-targeted oral delivery system (GLT-ODS) has been extensively investigated and widely used in food science and engineering in these years, due to the targeted delivery property, controlled release profile, high biocompatibility and enhanced bioavailability of cargos. Herein, we comprehensively summarized the current advances in GLT-ODS for bioactive agent. Specifically, we systematically summarize the GLT-ODS for pre-agents (prebiotics and probiotics) and anti-agents (antibiotics and bacteriophages) according to the type of cargos. Through in-depth discussion of representative researches, we refined the limitations of existing research in carrier material and target selection, and drew a blueprint for the future technological research and development. We believe that GLT-ODS will become a safe, efficient, simple and precise GM management strategy for improvement of health and shine in the development of precision food and pharmaceutical engineering in future.http://www.sciencedirect.com/science/article/pii/S2772566922000568Gut lumen-targetedOral delivery systemsBioactive agentsGut microenvironmentFood engineering |
| spellingShingle | Junyu Liu Xiaobin Li Xiaopeng Zhang Runming Wang Sanyang Han Peiwu Qin Xin-Hui Xing Canyang Zhang Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome Journal of Future Foods Gut lumen-targeted Oral delivery systems Bioactive agents Gut microenvironment Food engineering |
| title | Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome |
| title_full | Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome |
| title_fullStr | Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome |
| title_full_unstemmed | Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome |
| title_short | Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome |
| title_sort | gut lumen targeted oral delivery system for bioactive agents to regulate gut microbiome |
| topic | Gut lumen-targeted Oral delivery systems Bioactive agents Gut microenvironment Food engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2772566922000568 |
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