Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

Abstract Pathogenic mycobacteria induce the formation of hypoxic granulomas during latent tuberculosis (TB) infection, in which the immune system contains, but fails to eliminate the mycobacteria. Fatty acid metabolism-related genes are relatively overrepresented in the mycobacterial genome and myco...

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Main Authors: Hua Yang, Fei Wang, Xinya Guo, Feng Liu, Zhonghua Liu, Xiangyang Wu, Mengmeng Zhao, Mingtong Ma, Haipeng Liu, Lianhua Qin, Lin Wang, Tianqi Tang, Wei Sha, Yang Wang, Jianxia Chen, Xiaochen Huang, Jie Wang, Cheng Peng, Ruijuan Zheng, Fen Tang, Lu Zhang, Chunyan Wu, Stefan H. Oehlers, Zhigang Song, Jialei She, Hua Feng, Xunwei Xie, Baoxue Ge
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00301-1

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