S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure
Abstract Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, r...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46973-7 |
| _version_ | 1797233469671079936 |
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| author | Jie Ma Yang Li Ping Li Xinying Yang Shuolin Zhu Ke Ma Fei Gao Hai Gao Hui Zhang Xin-liang Ma Jie Du Yulin Li |
| author_facet | Jie Ma Yang Li Ping Li Xinying Yang Shuolin Zhu Ke Ma Fei Gao Hai Gao Hui Zhang Xin-liang Ma Jie Du Yulin Li |
| author_sort | Jie Ma |
| collection | DOAJ |
| description | Abstract Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report causal effect of S100A8/A9 on heart failure in three independent cohorts using Mendelian randomization approach. Here, we show that S100A8/A9 is a predictor and potentially causal medicator for heart failure post-acute myocardial infarction. |
| first_indexed | 2024-04-24T16:16:40Z |
| format | Article |
| id | doaj.art-8926f98405b74097bb053ba5ea722977 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T16:16:40Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8926f98405b74097bb053ba5ea7229772024-03-31T11:26:06ZengNature PortfolioNature Communications2041-17232024-03-0115111310.1038/s41467-024-46973-7S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failureJie Ma0Yang Li1Ping Li2Xinying Yang3Shuolin Zhu4Ke Ma5Fei Gao6Hai Gao7Hui Zhang8Xin-liang Ma9Jie Du10Yulin Li11Beijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityDepartment of Emergency Medicine, Thomas Jefferson UniversityBeijing Anzhen Hospital of Capital Medical UniversityBeijing Anzhen Hospital of Capital Medical UniversityAbstract Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report causal effect of S100A8/A9 on heart failure in three independent cohorts using Mendelian randomization approach. Here, we show that S100A8/A9 is a predictor and potentially causal medicator for heart failure post-acute myocardial infarction.https://doi.org/10.1038/s41467-024-46973-7 |
| spellingShingle | Jie Ma Yang Li Ping Li Xinying Yang Shuolin Zhu Ke Ma Fei Gao Hai Gao Hui Zhang Xin-liang Ma Jie Du Yulin Li S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure Nature Communications |
| title | S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure |
| title_full | S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure |
| title_fullStr | S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure |
| title_full_unstemmed | S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure |
| title_short | S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure |
| title_sort | s100a8 a9 as a prognostic biomarker with causal effects for post acute myocardial infarction heart failure |
| url | https://doi.org/10.1038/s41467-024-46973-7 |
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