Important Requirements for the Selection of Internal Standards during the Development of Desorption/Ionization Assays for Drug Quantification in Biological Matrices—A Practical Example

Important Requirements for the Selection of Internal Standards during the Development of Desorption/Ionization Assays for Drug Quantification in Biological Matrices—A Practical Example

Desorption/ionization mass spectrometry (DI-MS) approaches allow for the rapid quantification of drugs in biological matrices using assays that can be validated according to regulatory guidelines. However, specific adaptations must be applied to create reliable quantification methods, depending on t...

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Bibliographic Details
Main Authors: Margaux Fresnais, Seda Karabulut, Yasmin Abou Zeed, Johannes Ungermann, Julia Benzel, Kristian W. Pajtler, Stefan M. Pfister, Walter E. Haefeli, Jürgen Burhenne, Rémi Longuespée
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
desorption/ionization
mass spectrometry
drug
quantification
biological matrices
Online Access:https://www.mdpi.com/1420-3049/27/3/690

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