Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma
Abstract Background Cutaneous T‐cell lymphomas (CTCLs) often have skin dryness and skin barrier dysfunctions, which are also seen in atopic dermatitis (AD). Expression of keratinocyte proline‐rich protein (KPRP) was decreased in the epidermis of AD, which led to barrier defects and further allergic...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12240 |
| _version_ | 1797334482115624960 |
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| author | Teruyoshi Hisamoto Hiraku Suga Issey Omori Yuka Mizuno Kenta Oka Hikari Boki Naomi Takahashi‐Shishido Tomonori Oka Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato |
| author_facet | Teruyoshi Hisamoto Hiraku Suga Issey Omori Yuka Mizuno Kenta Oka Hikari Boki Naomi Takahashi‐Shishido Tomonori Oka Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato |
| author_sort | Teruyoshi Hisamoto |
| collection | DOAJ |
| description | Abstract Background Cutaneous T‐cell lymphomas (CTCLs) often have skin dryness and skin barrier dysfunctions, which are also seen in atopic dermatitis (AD). Expression of keratinocyte proline‐rich protein (KPRP) was decreased in the epidermis of AD, which led to barrier defects and further allergic inflammation. Objectives The aim of this study was to analyze KPRP expression in CTCL. Materials & Methods Skin samples of CTCL and healthy control were collected, and KPRP mRNA expression in the skin tissue was analyzed. We also performed immunohistochemistry of KPRP protein. Results Keratinocyte proline‐rich protein (KPRP) mRNA expression was decreased compared with normal skin. KPRP expression was positively correlated with that of filaggrin and loricrin, and it was negatively correlated with serum interleukin‐2 receptor levels. Immunohistochemistry staining showed that KPRP was detected in upper part of granular layer of epidermis in normal skin and in early‐stage CTCL, but rarely detected in the advanced‐stage CTCL. Conclusion In conclusion, we revealed the decrease in KPRP expression in CTCL. |
| first_indexed | 2024-03-08T08:21:23Z |
| format | Article |
| id | doaj.art-892936d37e5f438b8bd4d67cd253c99c |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T08:21:23Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-892936d37e5f438b8bd4d67cd253c99c2024-02-02T05:42:32ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932022-08-015412012410.1002/cia2.12240Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphomaTeruyoshi Hisamoto0Hiraku Suga1Issey Omori2Yuka Mizuno3Kenta Oka4Hikari Boki5Naomi Takahashi‐Shishido6Tomonori Oka7Tomomitsu Miyagaki8Makoto Sugaya9Shinichi Sato10Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanDepartments of Dermatology St. Marianna University School of Medicine Kanagawa JapanDepartment of Dermatology International University of Health and Welfare Chiba JapanDepartment of Dermatology University of Tokyo Graduate School of Medicine Tokyo JapanAbstract Background Cutaneous T‐cell lymphomas (CTCLs) often have skin dryness and skin barrier dysfunctions, which are also seen in atopic dermatitis (AD). Expression of keratinocyte proline‐rich protein (KPRP) was decreased in the epidermis of AD, which led to barrier defects and further allergic inflammation. Objectives The aim of this study was to analyze KPRP expression in CTCL. Materials & Methods Skin samples of CTCL and healthy control were collected, and KPRP mRNA expression in the skin tissue was analyzed. We also performed immunohistochemistry of KPRP protein. Results Keratinocyte proline‐rich protein (KPRP) mRNA expression was decreased compared with normal skin. KPRP expression was positively correlated with that of filaggrin and loricrin, and it was negatively correlated with serum interleukin‐2 receptor levels. Immunohistochemistry staining showed that KPRP was detected in upper part of granular layer of epidermis in normal skin and in early‐stage CTCL, but rarely detected in the advanced‐stage CTCL. Conclusion In conclusion, we revealed the decrease in KPRP expression in CTCL.https://doi.org/10.1002/cia2.12240CTCLfilaggrinKPRPloricrinTh2 |
| spellingShingle | Teruyoshi Hisamoto Hiraku Suga Issey Omori Yuka Mizuno Kenta Oka Hikari Boki Naomi Takahashi‐Shishido Tomonori Oka Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma Journal of Cutaneous Immunology and Allergy CTCL filaggrin KPRP loricrin Th2 |
| title | Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma |
| title_full | Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma |
| title_fullStr | Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma |
| title_full_unstemmed | Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma |
| title_short | Decreased keratinocyte Proline‐Rich protein expression in cutaneous T‐cell lymphoma |
| title_sort | decreased keratinocyte proline rich protein expression in cutaneous t cell lymphoma |
| topic | CTCL filaggrin KPRP loricrin Th2 |
| url | https://doi.org/10.1002/cia2.12240 |
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