Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance
Systemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use of cisplatin monotherapy to manage a heavily pretreated TNBC patient sh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine
2020-07-01
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| Series: | Yeungnam University Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.e-yujm.org/upload/pdf/yujm-2019-00423.pdf |
| _version_ | 1818340583786151936 |
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| author | Dong Won Baek Ji-Young Park Soo Jung Lee Yee Soo Chae |
| author_facet | Dong Won Baek Ji-Young Park Soo Jung Lee Yee Soo Chae |
| author_sort | Dong Won Baek |
| collection | DOAJ |
| description | Systemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use of cisplatin monotherapy to manage a heavily pretreated TNBC patient showing poor response to therapy. The patient was a 51-year-old woman who had already undergone several lines of systemic chemotherapy for widespread TNBC. Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the tumor to be germline BRCA wild-type, cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of platinum for breast cancer. After three cycles of cisplatin treatment, the patient’s metastatic lesions dramatically improved without any major toxicity, and she completed 17 cycles with good response. This case study indicates that patients with heavily pretreated TNBC can potentially achieve a good response to cisplatin monotherapy. |
| first_indexed | 2024-12-13T15:45:13Z |
| format | Article |
| id | doaj.art-892ae99fccd54d39aa56ea876a180de6 |
| institution | Directory Open Access Journal |
| issn | 2384-0293 |
| language | English |
| last_indexed | 2024-12-13T15:45:13Z |
| publishDate | 2020-07-01 |
| publisher | Yeungnam University College of Medicine |
| record_format | Article |
| series | Yeungnam University Journal of Medicine |
| spelling | doaj.art-892ae99fccd54d39aa56ea876a180de62022-12-21T23:39:43ZengYeungnam University College of MedicineYeungnam University Journal of Medicine2384-02932020-07-0137323023510.12701/yujm.2019.004232466Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performanceDong Won Baek0Ji-Young Park1Soo Jung Lee2Yee Soo Chae3 Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea Kyungpook National University Cancer Research Institute, Daegu, Korea Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaSystemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use of cisplatin monotherapy to manage a heavily pretreated TNBC patient showing poor response to therapy. The patient was a 51-year-old woman who had already undergone several lines of systemic chemotherapy for widespread TNBC. Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the tumor to be germline BRCA wild-type, cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of platinum for breast cancer. After three cycles of cisplatin treatment, the patient’s metastatic lesions dramatically improved without any major toxicity, and she completed 17 cycles with good response. This case study indicates that patients with heavily pretreated TNBC can potentially achieve a good response to cisplatin monotherapy.http://www.e-yujm.org/upload/pdf/yujm-2019-00423.pdfantineoplastic agentscisplatindna repairtriple negative breast neoplasms |
| spellingShingle | Dong Won Baek Ji-Young Park Soo Jung Lee Yee Soo Chae Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance Yeungnam University Journal of Medicine antineoplastic agents cisplatin dna repair triple negative breast neoplasms |
| title | Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance |
| title_full | Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance |
| title_fullStr | Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance |
| title_full_unstemmed | Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance |
| title_short | Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance |
| title_sort | impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple negative breast cancer with poor performance |
| topic | antineoplastic agents cisplatin dna repair triple negative breast neoplasms |
| url | http://www.e-yujm.org/upload/pdf/yujm-2019-00423.pdf |
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