Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?
Lipid metabolism involves multiple biological processes. As one of the most important lipid metabolic pathways, fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine palmitoyltransferase (CPT) system, regulate host immune responses and thus are of great clinical significance. Th...
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| Format: | Article |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.760581/full |
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| author | Muyun Wang Kun Wang Ximing Liao Haiyang Hu Liangzhi Chen Linlin Meng Wei Gao Qiang Li |
| author_facet | Muyun Wang Kun Wang Ximing Liao Haiyang Hu Liangzhi Chen Linlin Meng Wei Gao Qiang Li |
| author_sort | Muyun Wang |
| collection | DOAJ |
| description | Lipid metabolism involves multiple biological processes. As one of the most important lipid metabolic pathways, fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine palmitoyltransferase (CPT) system, regulate host immune responses and thus are of great clinical significance. The effect of the CPT system on different tissues or organs is complex: the deficiency or over-activation of CPT disrupts the immune homeostasis by causing energy metabolism disorder and inflammatory oxidative damage and therefore contributes to the development of various acute and chronic inflammatory disorders and cancer. Accordingly, agonists or antagonists targeting the CPT system may become novel approaches for the treatment of diseases. In this review, we first briefly describe the structure, distribution, and physiological action of the CPT system. We then summarize the pathophysiological role of the CPT system in chronic obstructive pulmonary disease, bronchial asthma, acute lung injury, chronic granulomatous disease, nonalcoholic fatty liver disease, hepatic ischemia–reperfusion injury, kidney fibrosis, acute kidney injury, cardiovascular disorders, and cancer. We are also concerned with the current knowledge in either preclinical or clinical studies of various CPT activators/inhibitors for the management of diseases. These compounds range from traditional Chinese medicines to novel nanodevices. Although great efforts have been made in studying the different kinds of CPT agonists/antagonists, only a few pharmaceuticals have been applied for clinical uses. Nevertheless, research on CPT activation or inhibition highlights the pharmacological modulation of CPT-dependent FAO, especially on different CPT isoforms, as a promising anti-inflammatory/antitumor therapeutic strategy for numerous disorders. |
| first_indexed | 2024-12-18T01:10:17Z |
| format | Article |
| id | doaj.art-892af5351f5941f185005cf932d3a128 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-18T01:10:17Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-892af5351f5941f185005cf932d3a1282022-12-21T21:26:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.760581760581Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?Muyun Wang0Kun Wang1Ximing Liao2Haiyang Hu3Liangzhi Chen4Linlin Meng5Wei Gao6Qiang Li7Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaLipid metabolism involves multiple biological processes. As one of the most important lipid metabolic pathways, fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine palmitoyltransferase (CPT) system, regulate host immune responses and thus are of great clinical significance. The effect of the CPT system on different tissues or organs is complex: the deficiency or over-activation of CPT disrupts the immune homeostasis by causing energy metabolism disorder and inflammatory oxidative damage and therefore contributes to the development of various acute and chronic inflammatory disorders and cancer. Accordingly, agonists or antagonists targeting the CPT system may become novel approaches for the treatment of diseases. In this review, we first briefly describe the structure, distribution, and physiological action of the CPT system. We then summarize the pathophysiological role of the CPT system in chronic obstructive pulmonary disease, bronchial asthma, acute lung injury, chronic granulomatous disease, nonalcoholic fatty liver disease, hepatic ischemia–reperfusion injury, kidney fibrosis, acute kidney injury, cardiovascular disorders, and cancer. We are also concerned with the current knowledge in either preclinical or clinical studies of various CPT activators/inhibitors for the management of diseases. These compounds range from traditional Chinese medicines to novel nanodevices. Although great efforts have been made in studying the different kinds of CPT agonists/antagonists, only a few pharmaceuticals have been applied for clinical uses. Nevertheless, research on CPT activation or inhibition highlights the pharmacological modulation of CPT-dependent FAO, especially on different CPT isoforms, as a promising anti-inflammatory/antitumor therapeutic strategy for numerous disorders.https://www.frontiersin.org/articles/10.3389/fphar.2021.760581/fullcarnitine palmitoyltransferase (CPT)fatty acid oxidation (FAO)inflammatory diseasescancersCPT activatorCPT inhibitor |
| spellingShingle | Muyun Wang Kun Wang Ximing Liao Haiyang Hu Liangzhi Chen Linlin Meng Wei Gao Qiang Li Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy? Frontiers in Pharmacology carnitine palmitoyltransferase (CPT) fatty acid oxidation (FAO) inflammatory diseases cancers CPT activator CPT inhibitor |
| title | Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy? |
| title_full | Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy? |
| title_fullStr | Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy? |
| title_full_unstemmed | Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy? |
| title_short | Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy? |
| title_sort | carnitine palmitoyltransferase system a new target for anti inflammatory and anticancer therapy |
| topic | carnitine palmitoyltransferase (CPT) fatty acid oxidation (FAO) inflammatory diseases cancers CPT activator CPT inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.760581/full |
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