Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice

Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice

Acute respiratory distress syndrome (ARDS) is a life-threatening disorder with a high rate of mortality. Complement activation in ARDS initiates a robust inflammatory reaction that can cause progressive endothelial injury in the lung. Here, we tested whether inhibition of the lectin pathway of compl...

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Bibliographic Details
Main Authors: Youssif M. Ali, Nicholas J. Lynch, Ahmed A. Shaaban, Dina E. Rizk, Shaymaa H. Abdel-Rahman, Priyanka Khatri, Munehisa Yabuki, Sadam Yaseen, Thomas Dudler, Gregory Demopulos, Wilhelm J. Schwaeble
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
ARDS
lectin pathway
lung injury
complement therapeutics
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192767/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192767/full

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