Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study
Chronic smoking impairs brain functions in the prefrontal cortex and the projecting meso-cortical limbic system. The purpose of this pilot study is to examine whether modulating the frontal brain activity using high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve smoking ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2018.00344/full |
| _version_ | 1829107222181838848 |
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| author | Da Chang Jian Zhang Wei Peng Zhuowen Shen Xin Gao Youhong Du Qiu Ge Donghui Song Yuanqi Shang Ze Wang Ze Wang |
| author_facet | Da Chang Jian Zhang Wei Peng Zhuowen Shen Xin Gao Youhong Du Qiu Ge Donghui Song Yuanqi Shang Ze Wang Ze Wang |
| author_sort | Da Chang |
| collection | DOAJ |
| description | Chronic smoking impairs brain functions in the prefrontal cortex and the projecting meso-cortical limbic system. The purpose of this pilot study is to examine whether modulating the frontal brain activity using high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve smoking cessation and to explore the changing pattern of the brain activity after treatment. Fourteen treatment-seeking smokers were offered a program involving 10 days of rTMS treatment with a follow-up for another 25 days. A frequency of 20 Hz rTMS was sequentially applied on the left dorso-lateral prefrontal cortex (DLPFC) and the superior medial frontal cortex (SMFC). The carbon monoxide (CO) level, withdrawal, craving scales, and neuroimaging data were collected. Ten smokers completed the entire treatment program, and 90% of them did not smoke during the 25-day follow-up time. A significant smoking craving reduction and resting brain activity reduction measured by the cerebral blood flow (CBF) and brain entropy (BEN) were observed after 10 days of 20 Hz rTMS treatments compared to the baseline. Although limited by sample size, these pilot findings definitely showed a high potential of multiple-target high-frequency rTMS in smoking cessation and the utility of fMRI for objectively assessing the treatment effects. |
| first_indexed | 2024-12-12T06:34:20Z |
| format | Article |
| id | doaj.art-892c9d67cd0f41bd9e7cc4b7ede9b233 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-12T06:34:20Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-892c9d67cd0f41bd9e7cc4b7ede9b2332022-12-22T00:34:30ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-09-011210.3389/fnhum.2018.00344400750Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot StudyDa Chang0Jian Zhang1Wei Peng2Zhuowen Shen3Xin Gao4Youhong Du5Qiu Ge6Donghui Song7Yuanqi Shang8Ze Wang9Ze Wang10Department of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychology, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaDepartment of Radiology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United StatesChronic smoking impairs brain functions in the prefrontal cortex and the projecting meso-cortical limbic system. The purpose of this pilot study is to examine whether modulating the frontal brain activity using high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve smoking cessation and to explore the changing pattern of the brain activity after treatment. Fourteen treatment-seeking smokers were offered a program involving 10 days of rTMS treatment with a follow-up for another 25 days. A frequency of 20 Hz rTMS was sequentially applied on the left dorso-lateral prefrontal cortex (DLPFC) and the superior medial frontal cortex (SMFC). The carbon monoxide (CO) level, withdrawal, craving scales, and neuroimaging data were collected. Ten smokers completed the entire treatment program, and 90% of them did not smoke during the 25-day follow-up time. A significant smoking craving reduction and resting brain activity reduction measured by the cerebral blood flow (CBF) and brain entropy (BEN) were observed after 10 days of 20 Hz rTMS treatments compared to the baseline. Although limited by sample size, these pilot findings definitely showed a high potential of multiple-target high-frequency rTMS in smoking cessation and the utility of fMRI for objectively assessing the treatment effects.https://www.frontiersin.org/article/10.3389/fnhum.2018.00344/fullsmoking cessationrepetitive transcranial magnetic stimulationbrain entropycerebral blood flowleft dorso-lateral prefrontal cortexsuperior medial frontal cortex |
| spellingShingle | Da Chang Jian Zhang Wei Peng Zhuowen Shen Xin Gao Youhong Du Qiu Ge Donghui Song Yuanqi Shang Ze Wang Ze Wang Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study Frontiers in Human Neuroscience smoking cessation repetitive transcranial magnetic stimulation brain entropy cerebral blood flow left dorso-lateral prefrontal cortex superior medial frontal cortex |
| title | Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study |
| title_full | Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study |
| title_fullStr | Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study |
| title_full_unstemmed | Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study |
| title_short | Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study |
| title_sort | smoking cessation with 20 hz repetitive transcranial magnetic stimulation rtms applied to two brain regions a pilot study |
| topic | smoking cessation repetitive transcranial magnetic stimulation brain entropy cerebral blood flow left dorso-lateral prefrontal cortex superior medial frontal cortex |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2018.00344/full |
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