P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.
Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3720591?pdf=render |
| _version_ | 1818566478401634304 |
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| author | Tsung-Chang Sung Zhijiang Chen Sandrine Thuret Marçal Vilar Fred H Gage Roland Riek Kuo-Fen Lee |
| author_facet | Tsung-Chang Sung Zhijiang Chen Sandrine Thuret Marçal Vilar Fred H Gage Roland Riek Kuo-Fen Lee |
| author_sort | Tsung-Chang Sung |
| collection | DOAJ |
| description | Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans. |
| first_indexed | 2024-12-14T01:54:12Z |
| format | Article |
| id | doaj.art-892cb4cac9974abdb6bb42f526d6949d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T01:54:12Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-892cb4cac9974abdb6bb42f526d6949d2022-12-21T23:21:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6928610.1371/journal.pone.0069286P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.Tsung-Chang SungZhijiang ChenSandrine ThuretMarçal VilarFred H GageRoland RiekKuo-Fen LeeFas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans.http://europepmc.org/articles/PMC3720591?pdf=render |
| spellingShingle | Tsung-Chang Sung Zhijiang Chen Sandrine Thuret Marçal Vilar Fred H Gage Roland Riek Kuo-Fen Lee P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS ONE |
| title | P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. |
| title_full | P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. |
| title_fullStr | P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. |
| title_full_unstemmed | P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. |
| title_short | P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. |
| title_sort | p45 forms a complex with fadd and promotes neuronal cell survival following spinal cord injury |
| url | http://europepmc.org/articles/PMC3720591?pdf=render |
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