The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study

The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study

Abstract Background Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by Western diet (WD) intake. The current study uncovers the molecular sig...

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Bibliographic Details
Main Authors: Guiyan Yang, Prasant K. Jena, Ying Hu, Lili Sheng, Shin-Yu Chen, Carolyn M. Slupsky, Ryan Davis, Clifford G. Tepper, Yu-Jui Yvonne Wan
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Biomarker Research
Subjects:
Liver
Metabolic disease
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Hepatocellular carcinoma
Bile acid
Online Access:https://doi.org/10.1186/s40364-023-00458-9

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