Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China
Background Dong people in Southwest China are officially recognised as an ethnic group, but there has been a lack of population genetic research on this group, especially based on mitochondrial DNA data. Aim To study the sequences and haplogroups of the mitochondrial DNA control region in a typical...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2022.2131334 |
| _version_ | 1797685180144549888 |
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| author | Zheng Ren Yuhang Feng Hongling Zhang Qiyan Wang Meiqing Yang Yubo Liu Cuiyun Le Jie Wang Jiang Huang |
| author_facet | Zheng Ren Yuhang Feng Hongling Zhang Qiyan Wang Meiqing Yang Yubo Liu Cuiyun Le Jie Wang Jiang Huang |
| author_sort | Zheng Ren |
| collection | DOAJ |
| description | Background Dong people in Southwest China are officially recognised as an ethnic group, but there has been a lack of population genetic research on this group, especially based on mitochondrial DNA data. Aim To study the sequences and haplogroups of the mitochondrial DNA control region in a typical Dong population, and to provide help for the construction of a forensic mitochondrial DNA analysis reference database in East Asia. Subjects and methods The sequences of the mitochondrial DNA control region were analysed in 200 individuals of Dong in Guizhou. The haplotype frequencies, haplogroup distribution and paired Fst values of Guizhou Dong and 51 other populations in the world were calculated and explained to explore the genetic polymorphism and population relationships. Results A total of 180 haplotypes were detected, with frequencies of 0.005–0.02. All haplotypes were assigned to 97 different haplogroups. The haplotype diversity and random matching probability were 0.998643 and 0.00635, respectively. The paired Fst values and correlation p values of 52 populations showed that the Guizhou Dong had the closest genetic relationship with the Henan Han and the Guizhou Miao in China, and were closest to the Punjab population in Pakistan and the Kashmiri population when compared with the world populations. Conclusions Our study was based on the matrilineal genetic structure of Guizhou Dong to study mitochondrial DNA, which was helpful to promote the establishment of the forensic DNA reference database in East Asia and provide reference for anthropological research. |
| first_indexed | 2024-03-12T00:40:25Z |
| format | Article |
| id | doaj.art-892ee0b4e64d4714847a6765cca1f819 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:40:25Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-892ee0b4e64d4714847a6765cca1f8192023-09-15T08:45:20ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332022-11-01497-835436010.1080/03014460.2022.21313342131334Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest ChinaZheng Ren0Yuhang Feng1Hongling Zhang2Qiyan Wang3Meiqing Yang4Yubo Liu5Cuiyun Le6Jie Wang7Jiang Huang8Department of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityBackground Dong people in Southwest China are officially recognised as an ethnic group, but there has been a lack of population genetic research on this group, especially based on mitochondrial DNA data. Aim To study the sequences and haplogroups of the mitochondrial DNA control region in a typical Dong population, and to provide help for the construction of a forensic mitochondrial DNA analysis reference database in East Asia. Subjects and methods The sequences of the mitochondrial DNA control region were analysed in 200 individuals of Dong in Guizhou. The haplotype frequencies, haplogroup distribution and paired Fst values of Guizhou Dong and 51 other populations in the world were calculated and explained to explore the genetic polymorphism and population relationships. Results A total of 180 haplotypes were detected, with frequencies of 0.005–0.02. All haplotypes were assigned to 97 different haplogroups. The haplotype diversity and random matching probability were 0.998643 and 0.00635, respectively. The paired Fst values and correlation p values of 52 populations showed that the Guizhou Dong had the closest genetic relationship with the Henan Han and the Guizhou Miao in China, and were closest to the Punjab population in Pakistan and the Kashmiri population when compared with the world populations. Conclusions Our study was based on the matrilineal genetic structure of Guizhou Dong to study mitochondrial DNA, which was helpful to promote the establishment of the forensic DNA reference database in East Asia and provide reference for anthropological research.http://dx.doi.org/10.1080/03014460.2022.2131334mtdnaguizhou donghaplotypehaplogroup |
| spellingShingle | Zheng Ren Yuhang Feng Hongling Zhang Qiyan Wang Meiqing Yang Yubo Liu Cuiyun Le Jie Wang Jiang Huang Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China Annals of Human Biology mtdna guizhou dong haplotype haplogroup |
| title | Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China |
| title_full | Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China |
| title_fullStr | Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China |
| title_full_unstemmed | Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China |
| title_short | Genetic analysis of the mitochondrial DNA control region in Tai–Kadai-speaking Dong population in southwest China |
| title_sort | genetic analysis of the mitochondrial dna control region in tai kadai speaking dong population in southwest china |
| topic | mtdna guizhou dong haplotype haplogroup |
| url | http://dx.doi.org/10.1080/03014460.2022.2131334 |
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