Downregulation of type I collagen expression in the Achilles tendon by dexamethasone: a controlled laboratory study

Downregulation of type I collagen expression in the Achilles tendon by dexamethasone: a controlled laboratory study

Abstract Background Spontaneous Achilles tendon rupture associated with long-term dexamethasone (Dex) use has been reported. However, few studies have investigated the potential mechanism. The aim of this study was to evaluate the effects of oral Dex on type I collagen in humans and rats and its ass...

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Bibliographic Details
Main Authors: Zilu Ge, Hong Tang, Wan Chen, Yunjiao Wang, Chengsong Yuan, Xu Tao, Binghua Zhou, Kanglai Tang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Achilles tendon
Dexamethasone
Human
Rats
Type I collagen
Online Access:http://link.springer.com/article/10.1186/s13018-020-01602-z

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