Competition between electrostatic interactions and halogen bonding in the protein–ligand system: structural and thermodynamic studies of 5,6-dibromobenzotriazole-hCK2α complexes
Abstract CK2 is a member of the CMGC group of eukaryotic protein kinases and a cancer drug target. It can be efficiently inhibited by halogenated benzotriazoles and benzimidazoles. Depending on the scaffold, substitution pattern, and pH, these compounds are either neutral or anionic. Their binding p...
Main Authors: | Maria Winiewska-Szajewska, Honorata Czapinska, Magdalena Kaus-Drobek, Anna Fricke, Kinga Mieczkowska, Michał Dadlez, Matthias Bochtler, Jarosław Poznański |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-11-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-23611-0 |
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