The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications
There is increasing evidence that thyroid hormones (THs) work in an integrative fashion with androgen receptors (ARs) to regulate gonadal differentiatio n and reproductive function. Studies reveal that THs have interactions with the AR promoter region and increase AR expression. THs also have a role...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-05-01
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| Series: | European Thyroid Journal |
| Subjects: | |
| Online Access: | https://etj.bioscientifica.com/view/journals/etj/12/3/ETJ-22-0228.xml |
| _version_ | 1797835551641960448 |
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| author | Sepehr Torabinejad Caterina Miro Biagio Barone Ciro Imbimbo Felice Crocetto Monica Dentice |
| author_facet | Sepehr Torabinejad Caterina Miro Biagio Barone Ciro Imbimbo Felice Crocetto Monica Dentice |
| author_sort | Sepehr Torabinejad |
| collection | DOAJ |
| description | There is increasing evidence that thyroid hormones (THs) work in an integrative fashion with androgen receptors (ARs) to regulate gonadal differentiatio n and reproductive function. Studies reveal that THs have interactions with the AR promoter region and increase AR expression. THs also have a role in the regulation of enzymes involved in the biosynthesis of androgens, such as 5α-reductase, which is essential in the conversion of testosterone into its active form, 5α-dihydrotestosterone. Additionally, the presence of androgen response elements in the promoter regions of TH-related genes, such as deiodinases and TH receptor isoforms, has been identified in some vertebrates, indicating a mutual interaction between THs and ARs. Since the androgen signaling pathway, mediated by ARs, plays a key role in the formation and progression of prostate cancer (PCa), the existence of crosstalk between THs and ARs supports the epidemiologic and experimental evidence indicating a relationship between the high incidence of PCa and hyperthyroidism. This article aims to review the role of androgen-TH crosstalk in PCa and its implication in clinical management. As life expectancy is growing these days, it can increase the number of patients with PCa and the critical relevance of the disease. In order to gain better knowledge about PCa and to improve clinical management, it is essential to get better insight into the key factors related to the formation and progression of this cancer. |
| first_indexed | 2024-04-09T14:55:29Z |
| format | Article |
| id | doaj.art-8931e771cb9345ca8f6209fa8c356b2b |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-04-09T14:55:29Z |
| publishDate | 2023-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-8931e771cb9345ca8f6209fa8c356b2b2023-05-02T07:11:27ZengBioscientificaEuropean Thyroid Journal2235-08022023-05-01123113https://doi.org/10.1530/ETJ-22-0228The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implicationsSepehr Torabinejad0Caterina Miro1Biagio Barone2Ciro Imbimbo3Felice Crocetto4Monica Dentice5Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico IIDepartment of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy; CEINGE – Biotecnologie Avanzate Scarl, Naples, Italy There is increasing evidence that thyroid hormones (THs) work in an integrative fashion with androgen receptors (ARs) to regulate gonadal differentiatio n and reproductive function. Studies reveal that THs have interactions with the AR promoter region and increase AR expression. THs also have a role in the regulation of enzymes involved in the biosynthesis of androgens, such as 5α-reductase, which is essential in the conversion of testosterone into its active form, 5α-dihydrotestosterone. Additionally, the presence of androgen response elements in the promoter regions of TH-related genes, such as deiodinases and TH receptor isoforms, has been identified in some vertebrates, indicating a mutual interaction between THs and ARs. Since the androgen signaling pathway, mediated by ARs, plays a key role in the formation and progression of prostate cancer (PCa), the existence of crosstalk between THs and ARs supports the epidemiologic and experimental evidence indicating a relationship between the high incidence of PCa and hyperthyroidism. This article aims to review the role of androgen-TH crosstalk in PCa and its implication in clinical management. As life expectancy is growing these days, it can increase the number of patients with PCa and the critical relevance of the disease. In order to gain better knowledge about PCa and to improve clinical management, it is essential to get better insight into the key factors related to the formation and progression of this cancer.https://etj.bioscientifica.com/view/journals/etj/12/3/ETJ-22-0228.xmlthyroid hormoneandrogensprostate cancer |
| spellingShingle | Sepehr Torabinejad Caterina Miro Biagio Barone Ciro Imbimbo Felice Crocetto Monica Dentice The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications European Thyroid Journal thyroid hormone androgens prostate cancer |
| title | The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications |
| title_full | The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications |
| title_fullStr | The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications |
| title_full_unstemmed | The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications |
| title_short | The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications |
| title_sort | androgen thyroid hormone crosstalk in prostate cancer and the clinical implications |
| topic | thyroid hormone androgens prostate cancer |
| url | https://etj.bioscientifica.com/view/journals/etj/12/3/ETJ-22-0228.xml |
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