Effect of HLA-B27 on Development of Psoriatic Arthropathy
Background: Psoriatic arthritis is a type of arthritis that can often affect some patients who suffer from psoriasis. Approximately 40-50% of individuals with psoriatic arthritis have the HLA-B27 genotype Objective: To investigate whether we could confirm the role of HLA-B27 alleles and psoriati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2019-06-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/55 |
| _version_ | 1818481775458910208 |
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| author | Galawisah A. Abdullah Haider H. Zalzala |
| author_facet | Galawisah A. Abdullah Haider H. Zalzala |
| author_sort | Galawisah A. Abdullah |
| collection | DOAJ |
| description |
Background: Psoriatic arthritis is a type of arthritis that can often affect some patients who suffer from psoriasis. Approximately 40-50% of individuals with psoriatic arthritis have the HLA-B27 genotype
Objective: To investigate whether we could confirm the role of HLA-B27 alleles and psoriatic arthritis in Iraqi Arab Muslims patients.
Method: A cross sectional case control comparative study included thirty Iraqi Arab Muslims who had psoriatic arthritis that consulted the Dermatological and Rheumatological Department in AL-Kindy Teaching Hospital from November 2014 to June 2015. HLA-genotyping for HLA-B27 were assessed. A control group consisted of fifty-one healthy volunteers among the staff of Al-Kindy College of Medicine that did not have psoriatic arthritis or family history of psoriasis. HLA-B*27allele was done by using an Exicycler TM 96 Real-time Quantitative Thermal Block (Bioneer, Daejeon, Korea) and Accupower, HLA-B27 real-time PCR kit (Bioneer, Daejeon , Korea)
Results: Plaque type psoriasis is more common than other types of psoriasis (66% versus 34%). There is no association between psoriatic arthritis and HLA-B27 with p-value of 0.1197 and Odds ratio (confidence interval) of 2.9375 (0.755-11.415).
Conclusions: HLA B*27 is not associated with psoriatic arthritis in Iraqi Arab Muslims patients.
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| first_indexed | 2024-12-10T11:39:33Z |
| format | Article |
| id | doaj.art-8932bb4e794d43b2b6cbe3388d14e933 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-12-10T11:39:33Z |
| publishDate | 2019-06-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-8932bb4e794d43b2b6cbe3388d14e9332022-12-22T01:50:19ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652019-06-0114210.47723/kcmj.v14i2.55Effect of HLA-B27 on Development of Psoriatic ArthropathyGalawisah A. AbdullahHaider H. Zalzala Background: Psoriatic arthritis is a type of arthritis that can often affect some patients who suffer from psoriasis. Approximately 40-50% of individuals with psoriatic arthritis have the HLA-B27 genotype Objective: To investigate whether we could confirm the role of HLA-B27 alleles and psoriatic arthritis in Iraqi Arab Muslims patients. Method: A cross sectional case control comparative study included thirty Iraqi Arab Muslims who had psoriatic arthritis that consulted the Dermatological and Rheumatological Department in AL-Kindy Teaching Hospital from November 2014 to June 2015. HLA-genotyping for HLA-B27 were assessed. A control group consisted of fifty-one healthy volunteers among the staff of Al-Kindy College of Medicine that did not have psoriatic arthritis or family history of psoriasis. HLA-B*27allele was done by using an Exicycler TM 96 Real-time Quantitative Thermal Block (Bioneer, Daejeon, Korea) and Accupower, HLA-B27 real-time PCR kit (Bioneer, Daejeon , Korea) Results: Plaque type psoriasis is more common than other types of psoriasis (66% versus 34%). There is no association between psoriatic arthritis and HLA-B27 with p-value of 0.1197 and Odds ratio (confidence interval) of 2.9375 (0.755-11.415). Conclusions: HLA B*27 is not associated with psoriatic arthritis in Iraqi Arab Muslims patients. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/55psoriatic arthritis,HLA-B*27,PCR. |
| spellingShingle | Galawisah A. Abdullah Haider H. Zalzala Effect of HLA-B27 on Development of Psoriatic Arthropathy مجله كليه طب الكندي psoriatic arthritis, HLA-B*27, PCR. |
| title | Effect of HLA-B27 on Development of Psoriatic Arthropathy |
| title_full | Effect of HLA-B27 on Development of Psoriatic Arthropathy |
| title_fullStr | Effect of HLA-B27 on Development of Psoriatic Arthropathy |
| title_full_unstemmed | Effect of HLA-B27 on Development of Psoriatic Arthropathy |
| title_short | Effect of HLA-B27 on Development of Psoriatic Arthropathy |
| title_sort | effect of hla b27 on development of psoriatic arthropathy |
| topic | psoriatic arthritis, HLA-B*27, PCR. |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/55 |
| work_keys_str_mv | AT galawisahaabdullah effectofhlab27ondevelopmentofpsoriaticarthropathy AT haiderhzalzala effectofhlab27ondevelopmentofpsoriaticarthropathy |