Criticality of timing for anti-HIV therapy initiation.
The time of initiation of antiretroviral therapy in HIV-1 infected patients has a determinant effect on the viral dynamics. The question is, how far can the therapy be delayed? Is sooner always better? We resort to clinical data and to microsimulations to forecast the dynamics of the viral load at t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3009726?pdf=render |
| _version_ | 1818147901806739456 |
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| author | Filippo Castiglione Paola Paci |
| author_facet | Filippo Castiglione Paola Paci |
| author_sort | Filippo Castiglione |
| collection | DOAJ |
| description | The time of initiation of antiretroviral therapy in HIV-1 infected patients has a determinant effect on the viral dynamics. The question is, how far can the therapy be delayed? Is sooner always better? We resort to clinical data and to microsimulations to forecast the dynamics of the viral load at therapy interruption after prolonged antiretroviral treatment. A computational model previously evaluated, produces results that are statistically adherent to clinical data. In addition, it allows a finer grain analysis of the impact of the therapy initiation point to the disease course. We find a swift increase of the viral density as a function of the time of initiation of the therapy measured when the therapy is stopped. In particular there is a critical time delay with respect to the infection instant beyond which the therapy does not affect the viral rebound. Initiation of the treatment is beneficial because it can down-regulate the immune activation, hence limiting viral replication and spread. |
| first_indexed | 2024-12-11T12:42:37Z |
| format | Article |
| id | doaj.art-8935d7e31d414f899911d99c8303fcec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T12:42:37Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8935d7e31d414f899911d99c8303fcec2022-12-22T01:06:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-01512e1529410.1371/journal.pone.0015294Criticality of timing for anti-HIV therapy initiation.Filippo CastiglionePaola PaciThe time of initiation of antiretroviral therapy in HIV-1 infected patients has a determinant effect on the viral dynamics. The question is, how far can the therapy be delayed? Is sooner always better? We resort to clinical data and to microsimulations to forecast the dynamics of the viral load at therapy interruption after prolonged antiretroviral treatment. A computational model previously evaluated, produces results that are statistically adherent to clinical data. In addition, it allows a finer grain analysis of the impact of the therapy initiation point to the disease course. We find a swift increase of the viral density as a function of the time of initiation of the therapy measured when the therapy is stopped. In particular there is a critical time delay with respect to the infection instant beyond which the therapy does not affect the viral rebound. Initiation of the treatment is beneficial because it can down-regulate the immune activation, hence limiting viral replication and spread.http://europepmc.org/articles/PMC3009726?pdf=render |
| spellingShingle | Filippo Castiglione Paola Paci Criticality of timing for anti-HIV therapy initiation. PLoS ONE |
| title | Criticality of timing for anti-HIV therapy initiation. |
| title_full | Criticality of timing for anti-HIV therapy initiation. |
| title_fullStr | Criticality of timing for anti-HIV therapy initiation. |
| title_full_unstemmed | Criticality of timing for anti-HIV therapy initiation. |
| title_short | Criticality of timing for anti-HIV therapy initiation. |
| title_sort | criticality of timing for anti hiv therapy initiation |
| url | http://europepmc.org/articles/PMC3009726?pdf=render |
| work_keys_str_mv | AT filippocastiglione criticalityoftimingforantihivtherapyinitiation AT paolapaci criticalityoftimingforantihivtherapyinitiation |