Immune Modulatory Effects of Vitamin D on Viral Infections
Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the skeletal system in the human body. Recent evidence has indicated that vitamin D als...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/9/2879 |
| _version_ | 1797553111986864128 |
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| author | Maheen Siddiqui Judhell S. Manansala Hana A. Abdulrahman Gheyath K. Nasrallah Maria K. Smatti Nadin Younes Asmaa A. Althani Hadi M. Yassine |
| author_facet | Maheen Siddiqui Judhell S. Manansala Hana A. Abdulrahman Gheyath K. Nasrallah Maria K. Smatti Nadin Younes Asmaa A. Althani Hadi M. Yassine |
| author_sort | Maheen Siddiqui |
| collection | DOAJ |
| description | Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the skeletal system in the human body. Recent evidence has indicated that vitamin D also plays an essential role in the immune response against viral infections and suggested that vitamin D deficiency increases susceptibility to viral infections as well as the risk of recurrent infections. For instance, low serum vitamin D levels were linked to increased occurrence of high burdens viral diseases such as hepatitis, influenza, Covid-19, and AIDS. As immune cells in infected patients are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with an infectious disease may extend beyond the impact on bone and calcium homeostasis. Even though numerous studies have highlighted the effect of vitamin D on the immune cells, vitamin D’s antiviral mechanism has not been fully established. This paper reviews the recent mechanisms by which vitamin D regulates the immune system, both innate and adaptive systems, and reflects on the link between serum vitamin D levels and viral infections. |
| first_indexed | 2024-03-10T16:10:47Z |
| format | Article |
| id | doaj.art-8938a69edb4444bb8ea18c3a53015fd8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:10:47Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8938a69edb4444bb8ea18c3a53015fd82023-11-20T14:27:55ZengMDPI AGNutrients2072-66432020-09-01129287910.3390/nu12092879Immune Modulatory Effects of Vitamin D on Viral InfectionsMaheen Siddiqui0Judhell S. Manansala1Hana A. Abdulrahman2Gheyath K. Nasrallah3Maria K. Smatti4Nadin Younes5Asmaa A. Althani6Hadi M. Yassine7College of Health Science-QU Health, Qatar University, Doha 2713, QatarCollege of Health Science-QU Health, Qatar University, Doha 2713, QatarBiomedical Research Center, Qatar University, Doha 2713, QatarCollege of Health Science-QU Health, Qatar University, Doha 2713, QatarBiomedical Research Center, Qatar University, Doha 2713, QatarCollege of Health Science-QU Health, Qatar University, Doha 2713, QatarCollege of Health Science-QU Health, Qatar University, Doha 2713, QatarCollege of Health Science-QU Health, Qatar University, Doha 2713, QatarViral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the skeletal system in the human body. Recent evidence has indicated that vitamin D also plays an essential role in the immune response against viral infections and suggested that vitamin D deficiency increases susceptibility to viral infections as well as the risk of recurrent infections. For instance, low serum vitamin D levels were linked to increased occurrence of high burdens viral diseases such as hepatitis, influenza, Covid-19, and AIDS. As immune cells in infected patients are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with an infectious disease may extend beyond the impact on bone and calcium homeostasis. Even though numerous studies have highlighted the effect of vitamin D on the immune cells, vitamin D’s antiviral mechanism has not been fully established. This paper reviews the recent mechanisms by which vitamin D regulates the immune system, both innate and adaptive systems, and reflects on the link between serum vitamin D levels and viral infections.https://www.mdpi.com/2072-6643/12/9/2879vitamin DdeficiencyhepatitisInfluenzaCovid-19AIDS |
| spellingShingle | Maheen Siddiqui Judhell S. Manansala Hana A. Abdulrahman Gheyath K. Nasrallah Maria K. Smatti Nadin Younes Asmaa A. Althani Hadi M. Yassine Immune Modulatory Effects of Vitamin D on Viral Infections Nutrients vitamin D deficiency hepatitis Influenza Covid-19 AIDS |
| title | Immune Modulatory Effects of Vitamin D on Viral Infections |
| title_full | Immune Modulatory Effects of Vitamin D on Viral Infections |
| title_fullStr | Immune Modulatory Effects of Vitamin D on Viral Infections |
| title_full_unstemmed | Immune Modulatory Effects of Vitamin D on Viral Infections |
| title_short | Immune Modulatory Effects of Vitamin D on Viral Infections |
| title_sort | immune modulatory effects of vitamin d on viral infections |
| topic | vitamin D deficiency hepatitis Influenza Covid-19 AIDS |
| url | https://www.mdpi.com/2072-6643/12/9/2879 |
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