Human Interleukin 23 Receptor Induces Cell Apoptosis in Mammalian Cells by Intrinsic Mitochondrial Pathway Associated with the Down-Regulation of RAS/Mitogen-Activated Protein Kinase and Signal Transducers and Activators of Transcription factor 3 Signaling Pathways
The composition of IL-23R complex is similar to that of the IL-12 receptor (IL-12R) complex with a shared IL-12R-β1 chain. The IL-12R-β1 heterodimerizes with IL-23R and IL-12R-β2 to form IL-23R and IL-12R complexes, respectively. The IL-12R-β2 has been shown to function as a tumor suppressor gene...
Main Authors: | Wei-Ye Shi, Chang-Yan Che, Li Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/14/12/24656 |
Similar Items
-
RAS/Mitogen-Activated Protein Kinase Signaling Pathway in Testicular Germ Cell Tumors
by: Angelo Onorato, et al.
Published: (2024-02-01) -
Effects of Magnoliae Flos on Atopic Dermatitis-Like Inflammation Evaluated via Extracellular Signal-regulated Kinase or Signal Transducers and Activators of Transcription 1/3 Signalling Pathways
by: Tae-Young Gil, et al.
Published: (2023-11-01) -
KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative Disorders
by: Elena Vendramini, et al.
Published: (2022-01-01) -
Genetic Interference of FGFR3 Impedes Invasion of Upper Tract Urothelial Carcinoma Cells by Alleviating RAS/MAPK Signal Activity
by: Gong-Kai Huang, et al.
Published: (2023-01-01) -
Exploring the Molecular Landscape of Myelofibrosis, with a Focus on Ras and Mitogen-Activated Protein (MAP) Kinase Signaling
by: Samuel B. Reynolds, et al.
Published: (2023-09-01)