Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site
Gene-gating of a MYC oncogenic super-enhancer (OSE) increases its expression in colon cancer cells in a poorly understood process. Here the authors show that MYC gating requires a CTCF binding site (CTCFBS) within the OSE that directs the stepwise trafficking of the OSE to the nuclear pore to facili...
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Bibliographic Details
| Main Authors: |
Ilyas Chachoua,
Ilias Tzelepis,
Hao Dai,
Jia Pei Lim,
Anna Lewandowska-Ronnegren,
Felipe Beccaria Casagrande,
Shuangyang Wu,
Johanna Vestlund,
Carolina Diettrich Mallet de Lima,
Deeksha Bhartiya,
Barbara A. Scholz,
Mirco Martino,
Rashid Mehmood,
Anita Göndör |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27868-3
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