Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site
Gene-gating of a MYC oncogenic super-enhancer (OSE) increases its expression in colon cancer cells in a poorly understood process. Here the authors show that MYC gating requires a CTCF binding site (CTCFBS) within the OSE that directs the stepwise trafficking of the OSE to the nuclear pore to facili...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27868-3 |
| _version_ | 1818753477470322688 |
|---|---|
| author | Ilyas Chachoua Ilias Tzelepis Hao Dai Jia Pei Lim Anna Lewandowska-Ronnegren Felipe Beccaria Casagrande Shuangyang Wu Johanna Vestlund Carolina Diettrich Mallet de Lima Deeksha Bhartiya Barbara A. Scholz Mirco Martino Rashid Mehmood Anita Göndör |
| author_facet | Ilyas Chachoua Ilias Tzelepis Hao Dai Jia Pei Lim Anna Lewandowska-Ronnegren Felipe Beccaria Casagrande Shuangyang Wu Johanna Vestlund Carolina Diettrich Mallet de Lima Deeksha Bhartiya Barbara A. Scholz Mirco Martino Rashid Mehmood Anita Göndör |
| author_sort | Ilyas Chachoua |
| collection | DOAJ |
| description | Gene-gating of a MYC oncogenic super-enhancer (OSE) increases its expression in colon cancer cells in a poorly understood process. Here the authors show that MYC gating requires a CTCF binding site (CTCFBS) within the OSE that directs the stepwise trafficking of the OSE to the nuclear pore to facilitate increased nuclear export of MYC mRNA, which results in a growth advantage. |
| first_indexed | 2024-12-18T05:07:59Z |
| format | Article |
| id | doaj.art-893a77cc51f74de0b36357c417ac2c2c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:07:59Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-893a77cc51f74de0b36357c417ac2c2c2022-12-21T21:19:57ZengNature PortfolioNature Communications2041-17232022-01-0113111310.1038/s41467-021-27868-3Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding siteIlyas Chachoua0Ilias Tzelepis1Hao Dai2Jia Pei Lim3Anna Lewandowska-Ronnegren4Felipe Beccaria Casagrande5Shuangyang Wu6Johanna Vestlund7Carolina Diettrich Mallet de Lima8Deeksha Bhartiya9Barbara A. Scholz10Mirco Martino11Rashid Mehmood12Anita Göndör13Department of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetDepartment of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Stråket 1, Karolinska InstitutetGene-gating of a MYC oncogenic super-enhancer (OSE) increases its expression in colon cancer cells in a poorly understood process. Here the authors show that MYC gating requires a CTCF binding site (CTCFBS) within the OSE that directs the stepwise trafficking of the OSE to the nuclear pore to facilitate increased nuclear export of MYC mRNA, which results in a growth advantage.https://doi.org/10.1038/s41467-021-27868-3 |
| spellingShingle | Ilyas Chachoua Ilias Tzelepis Hao Dai Jia Pei Lim Anna Lewandowska-Ronnegren Felipe Beccaria Casagrande Shuangyang Wu Johanna Vestlund Carolina Diettrich Mallet de Lima Deeksha Bhartiya Barbara A. Scholz Mirco Martino Rashid Mehmood Anita Göndör Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site Nature Communications |
| title | Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site |
| title_full | Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site |
| title_fullStr | Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site |
| title_full_unstemmed | Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site |
| title_short | Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site |
| title_sort | canonical wnt signaling dependent gating of myc requires a noncanonical ctcf function at a distal binding site |
| url | https://doi.org/10.1038/s41467-021-27868-3 |
| work_keys_str_mv | AT ilyaschachoua canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT iliastzelepis canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT haodai canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT jiapeilim canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT annalewandowskaronnegren canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT felipebeccariacasagrande canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT shuangyangwu canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT johannavestlund canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT carolinadiettrichmalletdelima canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT deekshabhartiya canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT barbaraascholz canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT mircomartino canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT rashidmehmood canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite AT anitagondor canonicalwntsignalingdependentgatingofmycrequiresanoncanonicalctcffunctionatadistalbindingsite |