Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

Patients with nonalcoholic steatohepatitis (NASH) have increased expression of liver monocyte chemoattractant protein-1 (MCP-1), but its cellular source and contribution to various aspects of NASH pathophysiology remain debated. We demonstrated increased liver CCL2 (which encodes MCP-1) expression i...

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Bibliographic Details
Main Authors: Jinku Kang, Jorge Postigo-Fernandez, KyeongJin Kim, Changyu Zhu, Junjie Yu, Marica Meroni, Brent Mayfield, Alberto Bartolomé, Dianne H. Dapito, Anthony W. Ferrante Jr., Paola Dongiovanni, Luca Valenti, Remi J. Creusot, Utpal B. Pajvani
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-02-01
Series:JCI Insight
Subjects:
Gastroenterology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.165369

Internet

https://doi.org/10.1172/jci.insight.165369

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