Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage

Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage

Currently, most antioxidants do not show any favorable clinical outcomes in reducing myocardial ischemia-reperfusion (I/R) injury, suggesting an urgent need for exploring a new regulator of redox homeostasis in I/R hearts. Here, using heart-specific transgenic (TG) and knockdown (KD) mouse models, t...

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Bibliographic Details
Main Authors:	Shan Deng, Kobina Essandoh, Xiaohong Wang, Yutian Li, Wei Huang, Jing Chen, Jiangtong Peng, Ding-Sheng Jiang, Xingjiang Mu, Chenran Wang, Tianqing Peng, Jun-Lin Guan, Yigang Wang, Anil Jegga, Kai Huang, Guo-Chang Fan
Format:	Article
Language:	English
Published:	Elsevier 2020-05-01
Series:	Redox Biology
Subjects:	Oxidative stress Myocardial ischemia-reperfusion Nrf2 p62 aggregation Cardiac autophagy Tsg101
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231720300021

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