Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study
Wen-Xia Hu, Jing-Cui Peng, Yun Wang, Hao Jin, Nan Geng Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050012, People’s Republic of ChinaCorrespondence: Nan Geng, Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, 1...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-04-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/efficacy-and-safety-of-gefitinib-plus-anlotinib-for-patients-with-egfr-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1811288916910669824 |
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| author | Hu WX Peng JC Wang Y Jin H Geng N |
| author_facet | Hu WX Peng JC Wang Y Jin H Geng N |
| author_sort | Hu WX |
| collection | DOAJ |
| description | Wen-Xia Hu, Jing-Cui Peng, Yun Wang, Hao Jin, Nan Geng Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050012, People’s Republic of ChinaCorrespondence: Nan Geng, Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, 12 Jian-Kang Road, Shijiazhuang, 050012, People’s Republic of China, Tel +86 13933852787, Email anbuchaonv2021@163.comObjective: This study was to investigate the efficacy and safety of gefitinib plus anlotinib for patients with EGFR positive advanced non-small cell lung cancer (NSCLC) in a first-line setting.Methods: A total of 36 patients with previously-untreated EGFR positive advanced NSCLC were included in this study retrospectively. All patients were administered with gefitinib plus anlotinib combination therapy. The efficacy of the patients was evaluated with the change of target lesion using imaging evidence according to RECIST 1.1 criteria and all the patients were followed up regularly. Adverse reactions were collected and documented during the combination administration. Univariate analysis according to the baseline characteristic subgroup was implemented using Log rank test and multivariate analysis was adjusted by Cox regression analysis.Results: All the 36 patients included in our study were available for efficacy and safety analysis. Best overall response of the patients during gefitinib plus anlotinib administration suggested that partial response was observed in 30 patients, stable disease was noted in five patients, and progressive disease was found in one patient, which yielded an objective response rate (ORR) of 83.3% (95% CI=67.2– 93.6%) and a disease control rate (DCR) of 97.2% (95% CI=85.5– 99.9%). Prognostic data indicated that the median progression-free survival (PFS) of the 36 patients with NSCLC was 15.2 months (95% CI=8.15– 22.26). Furthermore, the median overall survival (OS) of the 36 patients was 35.9 months (95% CI=22.77– 49.03). Additionally, the most common adverse reactions of the patients with NSCLC were diarrhea (63.9%), fatigue (58.3%), hypertension (50.0%), rash (44.4%), and nausea and vomiting (41.7%). Furthermore, ECOG performance status was associated with PFS of gefitinib plus anlotinib combination therapy in baseline characteristic subgroup analysis.Conclusion: Gefitinib plus anlotinib regimen demonstrated encouraging efficacy and an acceptable safety profile for patients with previously untreated EGFR positive NSCLC preliminarily. The conclusion should be validated in prospective clinical trials subsequently.Keywords: non-small cell lung cancer, EGFR mutation, anlotinib, gefitinib, efficacy, safety |
| first_indexed | 2024-04-13T03:45:56Z |
| format | Article |
| id | doaj.art-893e23850c6e44f29cb2b7a4beb12264 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T03:45:56Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-893e23850c6e44f29cb2b7a4beb122642022-12-22T03:04:01ZengDove Medical PressInternational Journal of General Medicine1178-70742022-04-01Volume 154453446474855Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory StudyHu WXPeng JCWang YJin HGeng NWen-Xia Hu, Jing-Cui Peng, Yun Wang, Hao Jin, Nan Geng Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050012, People’s Republic of ChinaCorrespondence: Nan Geng, Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, 12 Jian-Kang Road, Shijiazhuang, 050012, People’s Republic of China, Tel +86 13933852787, Email anbuchaonv2021@163.comObjective: This study was to investigate the efficacy and safety of gefitinib plus anlotinib for patients with EGFR positive advanced non-small cell lung cancer (NSCLC) in a first-line setting.Methods: A total of 36 patients with previously-untreated EGFR positive advanced NSCLC were included in this study retrospectively. All patients were administered with gefitinib plus anlotinib combination therapy. The efficacy of the patients was evaluated with the change of target lesion using imaging evidence according to RECIST 1.1 criteria and all the patients were followed up regularly. Adverse reactions were collected and documented during the combination administration. Univariate analysis according to the baseline characteristic subgroup was implemented using Log rank test and multivariate analysis was adjusted by Cox regression analysis.Results: All the 36 patients included in our study were available for efficacy and safety analysis. Best overall response of the patients during gefitinib plus anlotinib administration suggested that partial response was observed in 30 patients, stable disease was noted in five patients, and progressive disease was found in one patient, which yielded an objective response rate (ORR) of 83.3% (95% CI=67.2– 93.6%) and a disease control rate (DCR) of 97.2% (95% CI=85.5– 99.9%). Prognostic data indicated that the median progression-free survival (PFS) of the 36 patients with NSCLC was 15.2 months (95% CI=8.15– 22.26). Furthermore, the median overall survival (OS) of the 36 patients was 35.9 months (95% CI=22.77– 49.03). Additionally, the most common adverse reactions of the patients with NSCLC were diarrhea (63.9%), fatigue (58.3%), hypertension (50.0%), rash (44.4%), and nausea and vomiting (41.7%). Furthermore, ECOG performance status was associated with PFS of gefitinib plus anlotinib combination therapy in baseline characteristic subgroup analysis.Conclusion: Gefitinib plus anlotinib regimen demonstrated encouraging efficacy and an acceptable safety profile for patients with previously untreated EGFR positive NSCLC preliminarily. The conclusion should be validated in prospective clinical trials subsequently.Keywords: non-small cell lung cancer, EGFR mutation, anlotinib, gefitinib, efficacy, safetyhttps://www.dovepress.com/efficacy-and-safety-of-gefitinib-plus-anlotinib-for-patients-with-egfr-peer-reviewed-fulltext-article-IJGMnon-small cell lung canceregfr mutationanlotinibgefitinibefficacysafety |
| spellingShingle | Hu WX Peng JC Wang Y Jin H Geng N Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study International Journal of General Medicine non-small cell lung cancer egfr mutation anlotinib gefitinib efficacy safety |
| title | Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study |
| title_full | Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study |
| title_fullStr | Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study |
| title_full_unstemmed | Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study |
| title_short | Efficacy and Safety of Gefitinib Plus Anlotinib for Patients with EGFR Positive Advanced Non-Small-Cell Lung Cancer: A Retrospective Exploratory Study |
| title_sort | efficacy and safety of gefitinib plus anlotinib for patients with egfr positive advanced non small cell lung cancer a retrospective exploratory study |
| topic | non-small cell lung cancer egfr mutation anlotinib gefitinib efficacy safety |
| url | https://www.dovepress.com/efficacy-and-safety-of-gefitinib-plus-anlotinib-for-patients-with-egfr-peer-reviewed-fulltext-article-IJGM |
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