Poor nutritional status is associated with the severity of omicron infection in the older adults
Abstract Background The Omicron wave of Coronavirus disease 2019 (COVID-19) remains the dominant strain worldwide. The studies of nutritional status in geriatric people with COVID-19 Omicron variant are limited. Thus, the aim of this study was to investigate the incidence of poor nutritional status...
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08959-6 |
| _version_ | 1797350142100111360 |
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| author | Xiaohan Gu Yongchao Guo Yongmei Shi Yaxiong Lu Shihan Yang Yongmei Jiang Qianwen Jin Qing Yun Li |
| author_facet | Xiaohan Gu Yongchao Guo Yongmei Shi Yaxiong Lu Shihan Yang Yongmei Jiang Qianwen Jin Qing Yun Li |
| author_sort | Xiaohan Gu |
| collection | DOAJ |
| description | Abstract Background The Omicron wave of Coronavirus disease 2019 (COVID-19) remains the dominant strain worldwide. The studies of nutritional status in geriatric people with COVID-19 Omicron variant are limited. Thus, the aim of this study was to investigate the incidence of poor nutritional status among Omicron infected older patients, and to explore the correlation between the nutritional status and the severity of Omicron infection in older patients. Methods This is a retrospective cross-sectional study. According to the clinical symptoms, patients were divided into two groups: mild and moderate to severe. Mini Nutritional Assessment short-form (MNA-SF) was conducted when patients were admitted and poor nutritional status was defined as MNA-SF score of 0–11. The inflammatory markers including neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and systemic inflammatory index (SII) were calculated and compared between two groups. Results Total of 324 patients were enrolled, with median [interquartile range (IQR)] age of 73 (17) years. Overall, 241 cases were mild, 83 cases were moderate to severe at the time of diagnosis and that 54.3% of patients had poor nutritional status. Patients with poor nutritional status were found to be older (P < 0.001) and less vaccinated (P < 0.001), with a longer virus shedding duration (P = 0.022), more comorbidities (≥ 2) (P = 0.004) and higher value of NLR (P < 0.001), PLR (P < 0.001) and SII (P = 0.012). Vaccination, cycle threshold value in ORF1ab gene (OR CT value) and female, higher MNA-SF score was negatively connected with probability of moderate to severe infection. For every 1 score increase in MNA-SF, the odds ratio of moderate to severe infection decreased by 14.8% [adjusted odds ratio (aOR), 0.852; 95% confidence interval (CI): 0.734–0.988; P = 0.034]. Conclusions Older patients with poor nutritional status are more likely to develop moderate to severe Omicron infection. |
| first_indexed | 2024-03-08T12:40:30Z |
| format | Article |
| id | doaj.art-893ed9c393374d8797d8285752d8e2cc |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T12:40:30Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-893ed9c393374d8797d8285752d8e2cc2024-01-21T12:12:10ZengBMCBMC Infectious Diseases1471-23342024-01-012411710.1186/s12879-023-08959-6Poor nutritional status is associated with the severity of omicron infection in the older adultsXiaohan Gu0Yongchao Guo1Yongmei Shi2Yaxiong Lu3Shihan Yang4Yongmei Jiang5Qianwen Jin6Qing Yun Li7Department of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background The Omicron wave of Coronavirus disease 2019 (COVID-19) remains the dominant strain worldwide. The studies of nutritional status in geriatric people with COVID-19 Omicron variant are limited. Thus, the aim of this study was to investigate the incidence of poor nutritional status among Omicron infected older patients, and to explore the correlation between the nutritional status and the severity of Omicron infection in older patients. Methods This is a retrospective cross-sectional study. According to the clinical symptoms, patients were divided into two groups: mild and moderate to severe. Mini Nutritional Assessment short-form (MNA-SF) was conducted when patients were admitted and poor nutritional status was defined as MNA-SF score of 0–11. The inflammatory markers including neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and systemic inflammatory index (SII) were calculated and compared between two groups. Results Total of 324 patients were enrolled, with median [interquartile range (IQR)] age of 73 (17) years. Overall, 241 cases were mild, 83 cases were moderate to severe at the time of diagnosis and that 54.3% of patients had poor nutritional status. Patients with poor nutritional status were found to be older (P < 0.001) and less vaccinated (P < 0.001), with a longer virus shedding duration (P = 0.022), more comorbidities (≥ 2) (P = 0.004) and higher value of NLR (P < 0.001), PLR (P < 0.001) and SII (P = 0.012). Vaccination, cycle threshold value in ORF1ab gene (OR CT value) and female, higher MNA-SF score was negatively connected with probability of moderate to severe infection. For every 1 score increase in MNA-SF, the odds ratio of moderate to severe infection decreased by 14.8% [adjusted odds ratio (aOR), 0.852; 95% confidence interval (CI): 0.734–0.988; P = 0.034]. Conclusions Older patients with poor nutritional status are more likely to develop moderate to severe Omicron infection.https://doi.org/10.1186/s12879-023-08959-6Coronavirus Disease 2019 (COVID-19)Disease severityNutritional statusOmicron |
| spellingShingle | Xiaohan Gu Yongchao Guo Yongmei Shi Yaxiong Lu Shihan Yang Yongmei Jiang Qianwen Jin Qing Yun Li Poor nutritional status is associated with the severity of omicron infection in the older adults BMC Infectious Diseases Coronavirus Disease 2019 (COVID-19) Disease severity Nutritional status Omicron |
| title | Poor nutritional status is associated with the severity of omicron infection in the older adults |
| title_full | Poor nutritional status is associated with the severity of omicron infection in the older adults |
| title_fullStr | Poor nutritional status is associated with the severity of omicron infection in the older adults |
| title_full_unstemmed | Poor nutritional status is associated with the severity of omicron infection in the older adults |
| title_short | Poor nutritional status is associated with the severity of omicron infection in the older adults |
| title_sort | poor nutritional status is associated with the severity of omicron infection in the older adults |
| topic | Coronavirus Disease 2019 (COVID-19) Disease severity Nutritional status Omicron |
| url | https://doi.org/10.1186/s12879-023-08959-6 |
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