Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute
In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2023-09-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/7084 |
| _version_ | 1797662194084610048 |
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| author | Lukas Meier Marina Antillon Christian Burri Nakul Chitnis Yvette Endriss Jennifer Keiser Sarah Moore Pie Müller Melissa Penny Till S. Voss Pascal Mäser Jürg Utzinger |
| author_facet | Lukas Meier Marina Antillon Christian Burri Nakul Chitnis Yvette Endriss Jennifer Keiser Sarah Moore Pie Müller Melissa Penny Till S. Voss Pascal Mäser Jürg Utzinger |
| author_sort | Lukas Meier |
| collection | DOAJ |
| description |
In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery and development processes, often at a fraction of the costs of de novo developments. For 80 years, collaborating within a network of partnerships, the Swiss Tropical and Public Health Institute (Swiss TPH) has been working along a value chain from innovation to validation and application to combat poverty-related diseases. This article presents an overview of selected know-how repurposing initiatives conducted at Swiss TPH with a particular emphasis on the exploration of drug development pathways in the context of neglected tropical diseases and other infectious diseases of poverty, such as schistosomiasis, malaria and human African trypanosomiasis.
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| first_indexed | 2024-03-11T18:56:33Z |
| format | Article |
| id | doaj.art-893f70b540d3482ca499ff5f9881f1c1 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-03-11T18:56:33Z |
| publishDate | 2023-09-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-893f70b540d3482ca499ff5f9881f1c12023-10-11T00:46:22ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242023-09-0177910.2533/chimia.2023.582Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health InstituteLukas Meier0Marina Antillon1Christian Burri2Nakul Chitnis3Yvette Endriss4Jennifer Keiser5Sarah Moore6Pie Müller7Melissa Penny8Till S. Voss9Pascal Mäser10Jürg Utzinger11Swiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, Switzerland; Ifakara Health Institute, Bagamoyo Branch, Bagamoyo, TanzaniaSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, Switzerland;Swiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, Switzerland;Swiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, SwitzerlandSwiss Tropical and Public Health Institute, CH-4123 Allschwil, Switzerland; University of Basel, CH-4001 Basel, Switzerland In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery and development processes, often at a fraction of the costs of de novo developments. For 80 years, collaborating within a network of partnerships, the Swiss Tropical and Public Health Institute (Swiss TPH) has been working along a value chain from innovation to validation and application to combat poverty-related diseases. This article presents an overview of selected know-how repurposing initiatives conducted at Swiss TPH with a particular emphasis on the exploration of drug development pathways in the context of neglected tropical diseases and other infectious diseases of poverty, such as schistosomiasis, malaria and human African trypanosomiasis. https://www.chimia.ch/chimia/article/view/7084Drug developmentDrug discoveryHuman African trypanosomiasisMalariaNeglected tropical diseasesProduct development partnerships |
| spellingShingle | Lukas Meier Marina Antillon Christian Burri Nakul Chitnis Yvette Endriss Jennifer Keiser Sarah Moore Pie Müller Melissa Penny Till S. Voss Pascal Mäser Jürg Utzinger Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute CHIMIA Drug development Drug discovery Human African trypanosomiasis Malaria Neglected tropical diseases Product development partnerships |
| title | Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute |
| title_full | Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute |
| title_fullStr | Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute |
| title_full_unstemmed | Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute |
| title_short | Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute |
| title_sort | repurposing know how for drug development case studies from the swiss tropical and public health institute |
| topic | Drug development Drug discovery Human African trypanosomiasis Malaria Neglected tropical diseases Product development partnerships |
| url | https://www.chimia.ch/chimia/article/view/7084 |
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