Anticholinesterase Inhibition, Drug-Likeness Assessment, and Molecular Docking Evaluation of Milk Protein-Derived Opioid Peptides for the Control of Alzheimer’s Disease

Anticholinesterase Inhibition, Drug-Likeness Assessment, and Molecular Docking Evaluation of Milk Protein-Derived Opioid Peptides for the Control of Alzheimer’s Disease

The drug-likeness and pharmacokinetic properties of 23 dairy-protein-derived opioid peptides were studied using SwissADME and ADMETlab in silico tools. All the opioid peptides had poor drug-like properties based on violations of Lipinski’s rule-of-five. Moreover, prediction of their pharmacokinetic...

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Bibliographic Details
Main Authors: Dawei Ji, Jingying Ma, Junyi Dai, Min Xu, Paul W. R. Harris, Margaret A. Brimble, Dominic Agyei
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Dairy
Subjects:
casomorphins
opioid peptides
cholinesterase inhibitors
molecular docking
bioinformatics
Alzheimer’s disease
Online Access:https://www.mdpi.com/2624-862X/3/3/32

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