Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/11/6/599 |
| _version_ | 1797564816197419008 |
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| author | Neda Azizipour Rahi Avazpour Derek H. Rosenzweig Mohamad Sawan Abdellah Ajji |
| author_facet | Neda Azizipour Rahi Avazpour Derek H. Rosenzweig Mohamad Sawan Abdellah Ajji |
| author_sort | Neda Azizipour |
| collection | DOAJ |
| description | Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. This review highlights the background of biochip development. Herein, we focus on applications of LOC devices as a versatile tool for POC applications. We also review current progress in OOC platforms towards body-on-a-chip, and we provide concluding remarks and future perspectives for OOC platforms for POC applications. |
| first_indexed | 2024-03-10T19:03:19Z |
| format | Article |
| id | doaj.art-89452898cc914041b14e92f88cea676e |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T19:03:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-89452898cc914041b14e92f88cea676e2023-11-20T04:17:35ZengMDPI AGMicromachines2072-666X2020-06-0111659910.3390/mi11060599Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-ChipNeda Azizipour0Rahi Avazpour1Derek H. Rosenzweig2Mohamad Sawan3Abdellah Ajji4Institut de Génie Biomédical, Polytechnique Montréal, Montreal, QC H3C 3A7, CanadaDepartment of Chemical Engineering, Polytechnique Montréal, Montreal, QC H3C 3A7, CanadaDepartment of Surgery, McGill University, Montreal, QC H3G 1A4, CanadaPolystim Neurotech Laboratory, Electrical Engineering Department, Polytechnique Montreal, QC H3T 1J4, CanadaInstitut de Génie Biomédical, Polytechnique Montréal, Montreal, QC H3C 3A7, CanadaFollowing the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. This review highlights the background of biochip development. Herein, we focus on applications of LOC devices as a versatile tool for POC applications. We also review current progress in OOC platforms towards body-on-a-chip, and we provide concluding remarks and future perspectives for OOC platforms for POC applications.https://www.mdpi.com/2072-666X/11/6/599organ-on-a-chiplab-on-a-chipmicrofluidicsmicroengineeringBioMEMSpoint-of-care |
| spellingShingle | Neda Azizipour Rahi Avazpour Derek H. Rosenzweig Mohamad Sawan Abdellah Ajji Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip Micromachines organ-on-a-chip lab-on-a-chip microfluidics microengineering BioMEMS point-of-care |
| title | Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip |
| title_full | Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip |
| title_fullStr | Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip |
| title_full_unstemmed | Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip |
| title_short | Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip |
| title_sort | evolution of biochip technology a review from lab on a chip to organ on a chip |
| topic | organ-on-a-chip lab-on-a-chip microfluidics microengineering BioMEMS point-of-care |
| url | https://www.mdpi.com/2072-666X/11/6/599 |
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