Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs
Few routinely available biomarkers are clinically useful in assessing dogs with inflammatory protein-losing enteropathy caused by immunosuppressive-responsive enteropathy (IRE-PLE). Only the neutrophil to lymphocyte ratio (NLR) has been studied, while no information exists on the use of the albumin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/3/484 |
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| author | Federica Cagnasso Antonio Borrelli Enrico Bottero Elena Benvenuti Riccardo Ferriani Veronica Marchetti Piero Ruggiero Barbara Bruno Cristiana Maurella Paola Gianella |
| author_facet | Federica Cagnasso Antonio Borrelli Enrico Bottero Elena Benvenuti Riccardo Ferriani Veronica Marchetti Piero Ruggiero Barbara Bruno Cristiana Maurella Paola Gianella |
| author_sort | Federica Cagnasso |
| collection | DOAJ |
| description | Few routinely available biomarkers are clinically useful in assessing dogs with inflammatory protein-losing enteropathy caused by immunosuppressive-responsive enteropathy (IRE-PLE). Only the neutrophil to lymphocyte ratio (NLR) has been studied, while no information exists on the use of the albumin to globulin ratio (AGR) and C-reactive protein to albumin ratio (CRP/ALB). We aimed to evaluate the clinical significance of the NLR, AGR and CRP/ALB in a population of dogs with IRE-PLE. The medical records of 53 IRE-PLE dogs were reviewed at the time of diagnosis (T0) and 1 month after the initiation of immunosuppressants (T1). A control group of 68 healthy dogs was used for comparison. At T0, the median values of the NLR and AGR of sick dogs were significantly higher and lower than those of healthy dogs, respectively. With the increase in the chronic enteropathy activity index, AGR and CRP/ALB significantly decreased and increased, respectively. At T1, NLR and AGR significantly increased, while CRP/ALB significantly decreased. NLR, AGR and CRP/ALB did not differ significantly between dogs classified as responders and nonresponders according to the chronic enteropathy activity index. Further studies are needed to provide more information on this subject. |
| first_indexed | 2024-03-11T09:54:09Z |
| format | Article |
| id | doaj.art-89456916d8b5444db94995ff1f6469fc |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T09:54:09Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-89456916d8b5444db94995ff1f6469fc2023-11-16T16:01:29ZengMDPI AGAnimals2076-26152023-01-0113348410.3390/ani13030484Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy DogsFederica Cagnasso0Antonio Borrelli1Enrico Bottero2Elena Benvenuti3Riccardo Ferriani4Veronica Marchetti5Piero Ruggiero6Barbara Bruno7Cristiana Maurella8Paola Gianella9Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyEndovet Italia, Via A. Oroboni, 00100 Rome, ItalyEndovet Italia, Via A. Oroboni, 00100 Rome, ItalyEndovet Italia, Via A. Oroboni, 00100 Rome, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalyEndovet Italia, Via A. Oroboni, 00100 Rome, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyIstituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Via Bologna, 220, 10154 Torino, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyFew routinely available biomarkers are clinically useful in assessing dogs with inflammatory protein-losing enteropathy caused by immunosuppressive-responsive enteropathy (IRE-PLE). Only the neutrophil to lymphocyte ratio (NLR) has been studied, while no information exists on the use of the albumin to globulin ratio (AGR) and C-reactive protein to albumin ratio (CRP/ALB). We aimed to evaluate the clinical significance of the NLR, AGR and CRP/ALB in a population of dogs with IRE-PLE. The medical records of 53 IRE-PLE dogs were reviewed at the time of diagnosis (T0) and 1 month after the initiation of immunosuppressants (T1). A control group of 68 healthy dogs was used for comparison. At T0, the median values of the NLR and AGR of sick dogs were significantly higher and lower than those of healthy dogs, respectively. With the increase in the chronic enteropathy activity index, AGR and CRP/ALB significantly decreased and increased, respectively. At T1, NLR and AGR significantly increased, while CRP/ALB significantly decreased. NLR, AGR and CRP/ALB did not differ significantly between dogs classified as responders and nonresponders according to the chronic enteropathy activity index. Further studies are needed to provide more information on this subject.https://www.mdpi.com/2076-2615/13/3/484dogchronic enteropathyinflammatory bowel diseaseleukocytesclinical response |
| spellingShingle | Federica Cagnasso Antonio Borrelli Enrico Bottero Elena Benvenuti Riccardo Ferriani Veronica Marchetti Piero Ruggiero Barbara Bruno Cristiana Maurella Paola Gianella Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs Animals dog chronic enteropathy inflammatory bowel disease leukocytes clinical response |
| title | Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_full | Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_fullStr | Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_full_unstemmed | Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_short | Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_sort | comparative evaluation of peripheral blood neutrophil to lymphocyte ratio serum albumin to globulin ratio and serum c reactive protein to albumin ratio in dogs with inflammatory protein losing enteropathy and healthy dogs |
| topic | dog chronic enteropathy inflammatory bowel disease leukocytes clinical response |
| url | https://www.mdpi.com/2076-2615/13/3/484 |
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