Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study
The severity of Parkinson’s disease (PD) is developed by multifactorial factors. Falls can worsen disease severity. We previously found that frontal assessment battery (FAB) score was associated with a higher risk of future falls. This eight-year follow-up study aimed to verify whether factors inclu...
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MDPI AG
2021-05-01
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| Online Access: | https://www.mdpi.com/2035-8377/13/2/23 |
| _version_ | 1797532601490079744 |
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| author | Hiroshi Kataoka Kazuma Sugie |
| author_facet | Hiroshi Kataoka Kazuma Sugie |
| author_sort | Hiroshi Kataoka |
| collection | DOAJ |
| description | The severity of Parkinson’s disease (PD) is developed by multifactorial factors. Falls can worsen disease severity. We previously found that frontal assessment battery (FAB) score was associated with a higher risk of future falls. This eight-year follow-up study aimed to verify whether factors including low FAB score can be the risk of PD progression based on the Hoehn and Yahr scale. In total, 95 patients were initially enrolled in this research and 45 were included in the final follow-up. Then, the cohort was classified into patients with and without disease progression, defined by upgrade of Hoehn-Yahr stage. Differences in clinical characteristics between patients with disease progression and those without were evaluated using the Mann–Whitney U test. Eighteen independent variables were evaluated via a univariate logistic regression analysis. Of the 45 patients enrolled, 32 had disease progression and 13 had no progression. Age (<i>p</i> = 0.033), BFI score (<i>p</i> = 0.003), Zung self-rating depression (<i>p</i> = 0.011), and anxiety scale (<i>p</i> = 0.026) were significantly increased in patients who had disease progression than those with no disease progression. On multivariate logistic regression analysis, brief fatigue inventory (BFI) score (OR = 1.048, <i>p</i> = 0.045, 95% CI = 1.001–1.098) was significantly related to disease progression. All BFI subscores related to general fatigue. Fatigue could predict the progression of motor dysfunction severity over a longitudinal duration in patients with PD with disease progression, having declining physical and mental fatigue. |
| first_indexed | 2024-03-10T11:02:33Z |
| format | Article |
| id | doaj.art-8946a70c797e4d928ffe4bdb0a5efb3e |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-10T11:02:33Z |
| publishDate | 2021-05-01 |
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| series | Neurology International |
| spelling | doaj.art-8946a70c797e4d928ffe4bdb0a5efb3e2023-11-21T21:24:50ZengMDPI AGNeurology International2035-83772021-05-0113222423110.3390/neurolint13020023Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up StudyHiroshi Kataoka0Kazuma Sugie1Department of Neurology, Nara Medical University, Kashihara, Nara 634-8522, JapanDepartment of Neurology, Nara Medical University, Kashihara, Nara 634-8522, JapanThe severity of Parkinson’s disease (PD) is developed by multifactorial factors. Falls can worsen disease severity. We previously found that frontal assessment battery (FAB) score was associated with a higher risk of future falls. This eight-year follow-up study aimed to verify whether factors including low FAB score can be the risk of PD progression based on the Hoehn and Yahr scale. In total, 95 patients were initially enrolled in this research and 45 were included in the final follow-up. Then, the cohort was classified into patients with and without disease progression, defined by upgrade of Hoehn-Yahr stage. Differences in clinical characteristics between patients with disease progression and those without were evaluated using the Mann–Whitney U test. Eighteen independent variables were evaluated via a univariate logistic regression analysis. Of the 45 patients enrolled, 32 had disease progression and 13 had no progression. Age (<i>p</i> = 0.033), BFI score (<i>p</i> = 0.003), Zung self-rating depression (<i>p</i> = 0.011), and anxiety scale (<i>p</i> = 0.026) were significantly increased in patients who had disease progression than those with no disease progression. On multivariate logistic regression analysis, brief fatigue inventory (BFI) score (OR = 1.048, <i>p</i> = 0.045, 95% CI = 1.001–1.098) was significantly related to disease progression. All BFI subscores related to general fatigue. Fatigue could predict the progression of motor dysfunction severity over a longitudinal duration in patients with PD with disease progression, having declining physical and mental fatigue.https://www.mdpi.com/2035-8377/13/2/23ParkinsonfatigueHoehn-Yahr stagerisk factorserotonindopamine |
| spellingShingle | Hiroshi Kataoka Kazuma Sugie Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study Neurology International Parkinson fatigue Hoehn-Yahr stage risk factor serotonin dopamine |
| title | Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study |
| title_full | Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study |
| title_fullStr | Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study |
| title_full_unstemmed | Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study |
| title_short | Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study |
| title_sort | association between fatigue and hoehn yahr staging in parkinson s disease eight year follow up study |
| topic | Parkinson fatigue Hoehn-Yahr stage risk factor serotonin dopamine |
| url | https://www.mdpi.com/2035-8377/13/2/23 |
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