Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents
Resiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of pharmacological actions. The therapeutic window of RTX is broad, allowing for the full desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Intravesical RTX was sho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/20/15042 |
| _version_ | 1797573707180277760 |
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| author | Arpad Szallasi |
| author_facet | Arpad Szallasi |
| author_sort | Arpad Szallasi |
| collection | DOAJ |
| description | Resiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of pharmacological actions. The therapeutic window of RTX is broad, allowing for the full desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Intravesical RTX was shown to restore continence in a subset of patients with idiopathic and neurogenic detrusor overactivity. RTX can also ablate sensory neurons as a “molecular scalpel” to achieve permanent analgesia. This targeted (intrathecal or epidural) RTX therapy holds great promise in cancer pain management. Intra-articular RTX is undergoing clinical trials to treat moderate-to-severe knee pain in patients with osteoarthritis. Similar targeted approaches may be useful in the management of post-operative pain or pain associated with severe burn injuries. The current state of this field is reviewed, from preclinical studies through veterinary medicine to clinical trials. |
| first_indexed | 2024-03-10T21:12:51Z |
| format | Article |
| id | doaj.art-894747bb711044328fc68b9f45e9cfec |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:12:51Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-894747bb711044328fc68b9f45e9cfec2023-11-19T16:40:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201504210.3390/ijms242015042Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive AfferentsArpad Szallasi0Department of Pathology and Experimental Cancer Research, Semmelweis University, 1083 Budapest, HungaryResiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of pharmacological actions. The therapeutic window of RTX is broad, allowing for the full desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Intravesical RTX was shown to restore continence in a subset of patients with idiopathic and neurogenic detrusor overactivity. RTX can also ablate sensory neurons as a “molecular scalpel” to achieve permanent analgesia. This targeted (intrathecal or epidural) RTX therapy holds great promise in cancer pain management. Intra-articular RTX is undergoing clinical trials to treat moderate-to-severe knee pain in patients with osteoarthritis. Similar targeted approaches may be useful in the management of post-operative pain or pain associated with severe burn injuries. The current state of this field is reviewed, from preclinical studies through veterinary medicine to clinical trials.https://www.mdpi.com/1422-0067/24/20/15042resiniferatoxincapsaicinTRPV1 receptorcancer painosteoarthritic painincontinence |
| spellingShingle | Arpad Szallasi Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents International Journal of Molecular Sciences resiniferatoxin capsaicin TRPV1 receptor cancer pain osteoarthritic pain incontinence |
| title | Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents |
| title_full | Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents |
| title_fullStr | Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents |
| title_full_unstemmed | Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents |
| title_short | Resiniferatoxin: Nature’s Precision Medicine to Silence TRPV1-Positive Afferents |
| title_sort | resiniferatoxin nature s precision medicine to silence trpv1 positive afferents |
| topic | resiniferatoxin capsaicin TRPV1 receptor cancer pain osteoarthritic pain incontinence |
| url | https://www.mdpi.com/1422-0067/24/20/15042 |
| work_keys_str_mv | AT arpadszallasi resiniferatoxinnaturesprecisionmedicinetosilencetrpv1positiveafferents |