RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine

RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine

Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a TLR7/8 agonist (Imidazoquinoline (IMDQ)‐PEG‐Chol)...

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Bibliographic Details
Main Authors: Sonia Jangra, Gabriel Laghlali, Angela Choi, Raveen Rathnasinghe, Yong Chen, Soner Yildiz, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
influenza vaccine
adjuvant
ADCC
T cell
antibody class switching
HA stalk
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.974016/full

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