Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

Aptazyme and CRISPR/Cas gene editing system were widely used for regulating gene expression in various diseases, including cancer. This work aimed to reconstruct CRISPR/Cas13d tool for sensing hTERT exclusively based on the new device OFF-switch hTERT aptazyme that was inserted into the 3’ UTR of th...

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Bibliographic Details
Main Authors: Chengle Zhuang, Changshui Zhuang, Qun Zhou, Xueting Huang, Yaoting Gui, Yongqing Lai, Shangqi Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
CRISPR/Cas13d
hTERT
bladder cancer
aptazyme
degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.646412/full

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